How does gata6 affect stem cell aging?
Best insight from top research papers
GATA6 plays a role in stem cell aging by regulating cellular activities and gene expression. Reprogramming of cells using pluripotency markers can reverse aging, and in the case of synovial fluid-derived mesenchymal stem cells (MSCs), the expression of GATA6 is attenuated in reprogrammed cells, leading to a decrease in aging-related activities . In pancreatic ductal adenocarcinoma (PDAC), GATA6 inhibits stemness features of cancer cells by suppressing the Wnt/β-catenin signaling pathway . In hematopoietic stem cells (HSCs), GATA6 is significantly decreased with aging and its knockdown in young HSCs leads to skewed production of myeloid cells, indicating its role in HSC aging . Additionally, GATA6 levels are positively correlated with the efficiency of differentiation into cardiomyocytes, suggesting its potential as a biomarker for selecting the best pluripotent stem cell lines for cardiac differentiation . Overall, GATA6 is a versatile transcription factor that can regulate stem cell aging through various mechanisms .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| The provided paper does not mention anything about GATA6 and its effect on stem cell aging. | |
| The provided paper does not mention anything about how Gata6 affects stem cell aging. | |
5 Citations | The provided paper does not mention anything about how Gata6 affects stem cell aging. The paper focuses on the role of Gata6 in enhancing the potential of pluripotent stem cells to differentiate into cardiomyocytes. |
13 Citations | GATA6 is a critical regulator that is increased in aged mesenchymal stem cells (MSCs). It controls the downstream sonic hedgehog signaling and FOXP1 pathway to modulate cellular senescence and aging-related activities. |
29 Jun 2022 | The provided paper does not mention anything about how GATA6 affects stem cell aging. The paper focuses on the role of GATA6 in inhibiting the stemness features of pancreatic cancer cells through the Wnt/β-catenin signaling pathway. |
Related Questions
Is there a relationship between epigenetics and ageing?5 answersEpigenetics plays a crucial role in the aging process. Epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNA regulation, are implicated in aging-related diseases and the physiological onset of aging. Perturbations in gene expression due to genetic and environmental factors contribute to the decline in physiological function associated with aging. Epigenetic alterations, including changes in chromatin structure and DNA methylation patterns, are reversible modifications that influence gene expression without altering the underlying DNA sequence. Lifestyle factors like nutrition, exercise, and caloric restriction can impact epigenetic changes associated with aging, highlighting the potential for interventions to delay aging and promote healthy longevity through epigenetic regulation.
What are the effects of salicylic acid on senescence?4 answersSalicylic acid (SA) has various effects on senescence. SA delays fruit senescence by inhibiting ethylene (ET) biosynthesis and regulating the expression of ETHYLENE INSENSITIVE 3 (EIN3). Exogenous application of SA improves flower longevity, maintains membrane stability, and increases antioxidant enzyme activity in cut Nicotiana plumbaginifolia flowers. In a mouse model of Alzheimer's disease (AD), SAL, a compound derived from herbs, reverses AD-related changes by regulating the microbiota-gut-brain axis and modulating inflammation. Salidroside, another compound derived from herbs, ameliorates homocysteine-induced cell senescence in human umbilical vein endothelial cells (HUVECs) by inhibiting Kruppel-like factor 4 (KLF4). In Arabidopsis, ethylene and SA synergistically promote leaf senescence by the interaction between EIN3 and NPR1, leading to the expression of senescence-associated genes.
What role do GATA genes play in mammalian development?5 answersGATA genes play crucial roles in mammalian development, regulating cell fate decisions and tissue morphogenesis. They are involved in the development of tissues derived from all three germ layers, including the skin, brain, gonads, liver, hematopoietic, cardiovascular, and urogenital systems. GATA factors are essential for the development of the myocardium, endocardium, outflow tract, and cardiac function. They also participate in the transcriptional regulatory circuitry during the development of the sympathoadrenal and urogenital systems. In addition, GATA genes are important for the programming of blood stem cells and the specification of cardiac cells during development. Furthermore, GATA2 and GATA3 are master orchestrators of gene expression in trophoblast cells, playing multiple roles in trophoblast development and establishing distinct trophoblast cell types during placentation.
What mechanism does m6a affect vascular smooth muscle cells aging?5 answersm6a affects vascular smooth muscle cells aging through various mechanisms. One mechanism involves the activation of the mTOR pathway, which is enhanced in aged smooth muscle cells and contributes to the impairment of intracellular calcium (Ca2+) stores mobilization. Another mechanism is the phenotypic modulation of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic phenotype, which is associated with decreased cellular contractility and increased cell stiffness. Additionally, m6a modification may regulate VSMC senescence through the p53-p21 and p16-retinoblastoma protein (pRB) pathways, which control the process of cellular senescence. Furthermore, oxidative stress-induced transcription factors, such as HIF1α and NFκB, are implicated in regulating smooth muscle cell mineralocorticoid receptor (MR) transcription in aging cells, which drives aging-related vascular stiffness and cardiovascular disease.
How does the m6A landscape change during the stem cell niche emerging?4 answersThe m6A landscape during the emergence of the stem cell niche is not directly addressed in the provided abstracts.
Do changes in the m6A landscape lead to stem cell niche aging?4 answersChanges in the m6A landscape have not been directly addressed in the provided abstracts. However, the abstracts do discuss the role of the stem cell niche in aging and its impact on stem cell function. The niche, which is the microenvironment that supports stem cells, undergoes functional changes with age, including alterations in cellular components and extracellular factors. These changes in the niche can contribute to the decline in stem cell number and activity, leading to compromised tissue homeostasis and regeneration in older individuals. While the abstracts do not specifically mention the m6A landscape, they provide insights into the importance of the stem cell niche in stem cell aging. Further research is needed to determine the specific role of m6A modifications in the aging of the stem cell niche.