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How does genetic variation in ALDH2 affect susceptibility to hearing loss in asian? 

Grip strength
Acetaldehyde
Disulfiram
Ototoxicity
Hearing loss
Best insight from top research papers

Genetic variations in ALDH2 can impact susceptibility to various health conditions in Asians. ALDH2 rs671 polymorphism, prevalent in Asians, affects alcohol metabolism and has been linked to atrial fibrillation (AF) development. Additionally, ALDH2 variants have been associated with a higher risk of certain diseases like Alzheimer's and acute coronary syndrome. Moreover, a study identified inherited genetic variations in ACYP2 related to cisplatin-induced ototoxicity, highlighting the role of genetic factors in hearing loss susceptibility. Furthermore, ALDH2 rs671 has been linked to reduced muscle strength with aging in non-athletes, indicating a broader impact on physiological functions. Therefore, genetic variations in ALDH2 can influence susceptibility to hearing loss and other health issues in the Asian population.

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Papers (5)Insight
Open access•Journal Article•DOI
ALDH2 gene polymorphism is associated with fitness in the elderly Japanese population
K. Y. de Almeida, Mika Saito, Hiroki Homma, Yukina Mochizuki, Aoto Saito, Minoru Deguchi, Ayumu Kozuma, Takanobu Okamoto, Koichi Nakazato, Naoki Kikuchi 
05 Nov 2022-Journal of Physiological Anthropology
2 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Variant Aldehyde Dehydrogenase 2 ( ALDH2*2) as a Risk Factor for Mechanical LA Substrate Formation and Atrial Fibrillation with Modest Alcohol Consumption in Ethnic Asians
Chung-Lieh Hung, Chung-Lieh Hung, Kuo-Tzu Sung, Kuo-Tzu Sung, Shun-Chuan Chang, Yen-Yu Liu, Jen-Yuan Kuo, Jen-Yuan Kuo, Wen-Hung Huang, Cheng-Huang Su, Cheng-Huang Su, Chuan-Chuan Liu, Shin-Yi Tsai, Shin-Yi Tsai, Chia-Yuan Liu, Chia-Yuan Liu, An-Sheng Lee, Szu-Hua Pan, Shih-Wei Wang, Charles Jia-Yin Hou, Charles Jia-Yin Hou, Ta-Chuan Hung, Ta-Chuan Hung, Hung-I Yeh, Hung-I Yeh 
21 Oct 2021
6 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss.
Heng Xu, Giles W. Robinson, Jie Huang, Joshua Yew Suang Lim, Hui Zhang, Johnnie K. Bass, Alberto Broniscer, Murali Chintagumpala, Ute Bartels, Sridharan Gururangan, Tim Hassall, Michael Fisher, Richard J. Cohn, Tetsuji Yamashita, Tal Teitz, Jian Zuo, Arzu Onar-Thomas, Amar Gajjar, Clinton F. Stewart, Jun J. Yang 
01 Mar 2015-Nature Genetics
105 Citations
Not addressed in the paper.
Open access•Journal Article•DOI
Emerging Associations of the ALDH2*2 Polymorphism with Disease Susceptibility
Jennifer Gueldner, Christie M. Sayes, Erika L. Abel, Erica D. Bruce 
20 Apr 2016-Journal of Drug Metabolism and Toxicology
7 Citations
Not addressed in the paper.
Journal Article•DOI
ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college students
Susan E. Luczak, Shoshana H. Shea, Annie C. Hsueh, Jenss Chang, Lucinda G. Carr, Tamara L. Wall 
01 May 2006-Journal of Studies on Alcohol and Drugs
21 Citations
Not addressed in the paper.

Related Questions

What are the underlying genetic factors that increase the risk of meningitis in children, leading to hearing loss?4 answersGenetic factors that increase the risk of meningitis in children, leading to hearing loss, include variations in pathogen recognition genes such as Toll-like receptor 2 (TLR2). Other risk factors for hearing loss in children with meningitis include computed tomographic scan evidence of increased intracranial pressure, male sex, low glucose levels in the cerebrospinal fluid, Streptococcus pneumoniae as the causative organism, and the presence of nuchal rigidity. Additionally, exposure to ototoxic medications such as gentamicin, vancomycin, and furosemide, as well as physiological risk factors, independently increase the likelihood of hearing loss in neonatal care. Furthermore, genetic variations in multiple pathogen recognition and immune response genes, including TLR4 and TLR9, are associated with clinical features that determine severity and outcome of childhood bacterial meningitis, particularly hearing loss. These findings highlight the importance of early diagnosis, treatment, and close monitoring of hearing in children with meningitis to prevent complications and promote proper speech development.
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What is the cause of age related hearing loss?5 answersAge-related hearing loss (ARHL) is caused by a combination of factors. One leading hypothesis is a decrease in ear metabolism, but this is not the sole cause. Studies have shown that auditory organ metabolism decreases with age, but there is no correlation between metabolic rate and age-related auditory decline. Another factor is the loss of hair cells in the inner ear, which is well correlated with the degree of hearing loss. Additionally, there is evidence to suggest that ARHL is associated with the accumulation of β-amyloid and tau, which are hallmarks of Alzheimer's disease. Furthermore, potassium ion channel dysfunction in various parts of the auditory system, including outer hair cells and the stria vascularis, may contribute to ARHL. Finally, mutations in the tip-link protein cadherin-23 can also lead to age-related hearing loss.
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What causes hearing loss in older people?5 answersAge-related hearing loss in older people is caused by a combination of factors including exposure to noise and ototoxic chemicals, smoking, diet, physical inactivity, and the presence of chronic lifestyle diseases. Peripheral changes in the ear and degeneration in the auditory neural pathway also contribute to age-related hearing loss. Damage to multiple structures in the auditory system, such as the cochlea and neural pathways, can result in impaired hearing. Additionally, age-related hearing loss is associated with cognitive decline, dementia, falls, depression, and social isolation. Treatment options for age-related hearing loss include hearing amplification devices, cochlear implants, and other implantable devices. Preventive measures, such as addressing modifiable lifestyle risk factors and reducing oxidative stress, may help in preventing or delaying age-related hearing loss.
What are some diseases that can lead to hearing loss?5 answersHearing loss can occur due to various reasons, including genetic, congenital, acquired, and infectious diseases. Infectious diseases account for approximately 25% of all cases of profound hearing loss, with one-fifth of these cases being congenital. Some leading causes of hearing loss globally include illness, middle-ear disease, injury, age, overuse of certain medications, and exposure to damaging noise levels. The prevalence of hearing loss increases with age, and by age 65, one out of three individuals will suffer from hearing impairment sufficient to interfere with speech understanding. Hearing loss can be classified into three types: sensorineural, conductive, and mixed. Sensorineural hearing loss involves the inner ear, cochlea, or auditory nerve, while conductive hearing loss occurs when the outer or middle ear structures fail to optimally capture, collect, or transmit sound. Mixed hearing loss is a combination of conductive and sensorineural hearing loss. Some specific diseases that can lead to hearing loss include neoplastic changes, inflammatory diseases, otosclerosis, and labyrinthitis.

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