How does m1A contribute to stem cell fate determination in the stem cell niche?
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m1A contributes to stem cell fate determination in the stem cell niche through its role in gene expression regulation and epigenetic/transcriptional regulatory mechanisms. The levels of m1A in mRNA are associated with translation efficiency and can affect the balance between self-renewal and differentiation in stem cells . Additionally, m1A alteration patterns have been shown to be significantly related to tumor microenvironment (TME) complexity and immune cell infiltration in kidney renal clear cell carcinoma (KIRC) and pancreatic adenocarcinoma (PAAD) . Furthermore, m1A modification-related patterns have been identified in glioma, and differences in survival prognosis, stemness, genomic heterogeneity, TME, and immune cell infiltration have been observed between different clusters . These findings suggest that m1A plays a crucial role in stem cell fate determination by influencing gene expression, TME, and immune cell infiltration.
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09 Jun 2022 | The provided text does not mention anything about m1A's contribution to stem cell fate determination in the stem cell niche. |
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