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Yuanhui Mao
Researcher at Cornell University
Publications - 40
Citations - 1785
Yuanhui Mao is an academic researcher from Cornell University. The author has contributed to research in topics: Translation (biology) & Ribosome. The author has an hindex of 12, co-authored 33 publications receiving 1042 citations. Previous affiliations of Yuanhui Mao include Northwest A&F University & Peking University.
Papers
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Journal ArticleDOI
Base-Resolution Mapping Reveals Distinct m1A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts
Xiaoyu Li,Xushen Xiong,Meiling Zhang,Kun Wang,Ying Chen,Jun Zhou,Yuanhui Mao,Jia Lv,Danyang Yi,Xiao Wei Chen,Chu Wang,Shu-Bing Qian,Chengqi Yi +12 more
TL;DR: A base-resolution m1A profiling method is developed, based onm1A-induced misincorporation during reverse transcription, and distinct classes of m1 a methylome are revealed in the human transcriptome, providing a resource for functional studies of m 1A-mediated epitranscriptomic regulation.
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m 6 A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
TL;DR: It is demonstrated that the m6A reader YTHDC2 — which contains an RNA helicase domain — acts on the coding region to promotes mRNA translation by resolving secondary structures, and established the physiological significance of CDS methylation and uncovered non-overlapping function of m 6A reader proteins.
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m6A Facilitates eIF4F-Independent mRNA Translation
Ryan Alex Coots,Xiao-Min Liu,Yuanhui Mao,Leiming Dong,Jun Zhou,Ji Wan,Xingqian Zhang,Shu-Bing Qian +7 more
TL;DR: It is reported that N6-methyladenosine (m6A) facilitates mRNA translation that is resistant to eIF4F inactivation, and ABCF1 is identified as a critical mediator of m6A-promoted translation under both stress and physiological conditions.
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N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response.
Jun Zhou,Ji Wan,Xin Erica Shu,Yuanhui Mao,Xiao-Min Liu,Xin Yuan,Xingqian Zhang,Martin E. Hess,Jens C. Brüning,Shu-Bing Qian +9 more
TL;DR: It is reported that, in response to amino acid starvation, the reinitiation of ATF4 is not only governed by the eIF2α signaling pathway, but is also subjected to regulation by mRNA methylation in the form of N6-methyladenosine (m6A).
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Alternative ORFs and small ORFs: shedding light on the dark proteome.
TL;DR: Progress in the detection of alternative ORFs as well as in the understanding of functions and the regulation of their expression are discussed, to highlight recent advances in both eukaryotic and bacterial cells.