How does radiation Alter cell proliferation, cell death, or nutrient supply?
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Radiation exposure induces complex cellular responses leading to altered cell proliferation and cell death mechanisms. It triggers various modes of cell death, including apoptosis, necrosis, autophagy-dependent cell death, pyroptosis, ferroptosis, immunogenic cell death, and non-lethal processes . Additionally, radiation activates signaling pathways, affecting DNA damage recognition, repair, cell survival, and cell cycle regulation . While apoptosis and mitotic catastrophe are major cell deaths induced by radiation, senescence and alternative cell death modalities also play crucial roles in inhibiting the proliferative capacity of malignant cells post-irradiation . Furthermore, radiation can lead to rapid apoptosis and reduced cell proliferation, with subsequent increased proliferation in irradiated cell compartments, potentially causing gland dysfunction . Overall, radiation therapy's effects on cell proliferation and death are intricate, involving a range of molecular mechanisms and responses .
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| Papers (4) | Insight |
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| Radiation alters cell proliferation by inducing apoptosis, mitotic catastrophe, and senescence, impacting tumor cell death mechanisms and potentially enhancing therapy efficacy by targeting key molecules. | |
| Radiation induces rapid apoptosis and reduces cell proliferation initially, followed by increased proliferation, correlating with the irradiation dose, potentially leading to gland dysfunction due to high apoptotic and proliferative activity. | |
| Radiation alters cell death through mechanisms like apoptosis, necrosis, autophagy-dependent cell death, pyroptosis, ferroptosis, immunogenic cell death, and non-lethal processes, impacting cell proliferation and nutrient supply. | |
| Radiation alters cell proliferation and death through signaling pathways, DNA damage recognition, repair, and apoptosis mechanisms, impacting cellular responses to stress and survival. Nutrient supply is not directly addressed. |
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