How does the LOC modulate nociceptive processing in the brain?
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The brain's processing of nociceptive stimuli involves complex interactions among various regions. Studies have shown that nociceptive pain elicits distinct patterns in functional connectivity (FC) within specific brain networks, such as the cingulo-opercular, sensorimotor, emotional, and default mode networks . Additionally, the anterior cingulate cortex (ACC) and precuneus play roles in attention to pain, with noise distraction affecting their activation levels . Furthermore, transcranial direct current stimulation (tDCS) can modulate cortical excitability during pain processing, leading to changes in brain activation patterns in response to nociceptive stimulation . These findings collectively highlight the intricate modulation of nociceptive processing by various brain regions and external factors, shedding light on the neural mechanisms underlying pain perception.
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38 Citations | Transcranial direct current stimulation (tDCS) does not significantly alter cortical nociceptive processing but shows polarity-specific changes in brain activation regions like the hypothalamus and insula. |
37 Citations | The descending circuitry, including the LOC, modulates nociceptive processing by either reducing inhibition or increasing facilitation of neural signals, potentially contributing to primary headache disorders like migraine. |
29 Citations | The study shows that noise distraction selectively modulates affective pain processing by reducing unpleasantness ratings and P2 peak amplitude, indicating a role for the LOC in nociceptive processing. |
5 Citations | The cingulo-opercular network modulates nociceptive processing by exhibiting widespread and strong functional connectivity with sensorimotor and emotional networks, influencing pain perception in the brain. |
187 Citations | The paper discusses how fentanyl, a μ-opioid receptor agonist, selectively modulates nociceptive processing in the human brain while preserving vibrotactile sensation, as shown in PET studies. |
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