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How edta affect hydrogel made with alginate and cacl2?

Self-healing hydrogels

Controlled release

Calcium alginate

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EDTA (ethylenediaminetetraacetic acid) can impact hydrogels made with alginate and CaCl2 by chelating with calcium ions, potentially affecting the crosslinking process and properties of the hydrogel. The presence of EDTA may interfere with the formation of the alginate-Ca2+ "egg-box" structure, crucial for the mechanical properties and functionalities of the hydrogel. Additionally, EDTA's chelating properties could disrupt the synergy between covalent and ionic crosslinking in the hydrogel, potentially altering its mechanical strength, self-healing capabilities, adhesion properties, anti-freezing characteristics, and conductivity. Therefore, the inclusion of EDTA in the preparation of alginate-Ca2+ hydrogels may lead to modifications in their structure and performance, impacting their potential applications in various fields, such as drug delivery systems.

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Journal Article•DOI A new insight to the effect of calcium concentration on gelation process and physical properties of alginate films Jiwei Li, Yadong Wu, Jinmei He, Yudong Huang - Show less +3 more 08 Mar 2016-Journal of Materials Science 46 Citations	EDTA chelates Ca2+ ions in alginate-CaCl2 hydrogels, affecting crosslinking density. This influences gelation process, leading to varied physical properties of alginate films.
Open access•Journal Article Electroresponsive behavior of calcium alginate hydrogel under electric field Shao Xudan 01 Jan 2006-Chinese Journal of Materials Research 4 Citations	EDTA is not addressed in the paper. The study focuses on the swelling and electroresponsive behavior of calcium alginate hydrogels under electric fields in NaCl solutions.
Journal Article•DOI Effect of Sodium Alginate Content on the Properties of Chemical-Ionic Cross-Linked Hydrogel Nian Yi Zhang, Qing Song Zhang, Xue Feng Gao, Li Chen - Show less +3 more 01 Dec 2013-Advanced Materials Research	Not addressed in the paper.
Journal Article•DOI Effects of crosslinking ratio, model drugs, and electric field strength on electrically controlled release for alginate-based hydrogel Nophawan Paradee, Anuvat Sirivat, Sumonman Niamlang, Walaiporn Prissanaroon-Ouajai - Show less +3 more 22 Feb 2012-Journal of Materials Science: Materials in Medicine 63 Citations	Not addressed in the paper.
Journal Article•DOI Role of a high calcium ion content in extending the properties of alginate dual-crosslinked hydrogels Xiaojin Zhang, Kang Wang, Jiayuan Hu, Yuchen Zhang, Yu Dai, Fan Xia - Show less +5 more 15 Dec 2020-Journal of Materials Chemistry 75 Citations	Not addressed in the paper.

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Related Questions

Are there any others methods expect for reaction with CaCl2 to prepare alginate hydrogel?5 answersYes, there are alternative methods to prepare alginate hydrogel besides reacting with CaCl2. One method involves the use of divalent metal salt aqueous solution to induce gelation of alginate, resulting in a quick preparation of alginate hydrogel. Another approach utilizes a solution extrusion process with CaCO3 and D-glucono-δ-lactone as gelation agents, enabling the fabrication of homogeneous alginate hydrogels in a single step via extrusion, which is advantageous for mass production. Additionally, an apparatus has been developed for preparing alginate hydrogel particles through cross-linking alginate droplets and divalent cationic droplets, offering an innovative method for alginate hydrogel preparation. These methods showcase diverse techniques beyond the traditional CaCl2 reaction for the efficient production of alginate hydrogels.

Lead in calcium alginate wounddressings?5 answersCalcium alginate wound dressings have been studied for their ability to remove non-essential elements, such as lead, from contaminated water. The combination of sodium alginate (SA) and cellulose nanocrystals (CNC) has been used to create a film of calcium alginate with CNC, which showed adsorption of lead ions from solution. The adsorption of lead onto the film increased with time of contact, and the maximum adsorption capacity was found to be 3.5 mg per gram of film. The film was characterized by Fourier Transform Infrared (FTIR), Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM). The results suggest that calcium alginate films have the potential to remove lead from contaminated water and could be used in wound dressings for advanced wound care.

How much ca ions need to be added to alginate to crosslinking?5 answersThe amount of Ca ions needed to crosslink alginate varies depending on the desired properties of the resulting material. In one study, alginate films crosslinked with 2% (w/v) calcium chloride for 2 minutes exhibited the best overall performance, including increased tensile strength and light transmission, and decreased water vapor permeation. Another study investigated the effects of Ca ion concentration on the elasticities of alginate gels and found that the number of junctions formed was constant for Ca ion concentrations above 0.03 mol dm−3. Additionally, the concentration of Ca ions in the rinsing solution during the layer-by-layer adsorption technique affected the crosslinking and permeability of alginate-containing multilayers, with higher concentrations leading to increased thickness and decreased permeability. Therefore, the specific amount of Ca ions required for crosslinking alginate depends on the desired properties and the specific application of the material.

How does pH affect the swelling behavior of alginate?4 answersThe swelling behavior of alginate is affected by pH. Alginate hydrogels showed pH-responsive behavior, with different swelling properties under acidic and basic conditions. Under acidic conditions (pH 2), the swelling of alginate hydrogels decreased. On the other hand, under basic conditions (pH 10), the swelling of alginate hydrogels showed an on- and off-switchable behavior. The pH-dependent swelling of alginate hydrogels can be attributed to the interaction between the alginate polymer chains and the surrounding environment. The degree of swelling was found to be dependent on the concentration of acids and bases. Additionally, the swelling capacity of alginate hydrogels decreased with an increase in the ionic strength of the swelling medium. Overall, the pH of the environment plays a crucial role in determining the swelling behavior of alginate hydrogels.

Why does hydrogel starch with Cacl2 immersed in pbs or water turn into a gel?3 answersWhen hydrogel starch with CaCl2 is immersed in PBS or water, it turns into a gel due to the crosslinking between the starch and Ca2+ ions. The addition of CaCl2 reduces the viscosity of the starch and alters its rheological behaviors, resulting in the formation of a gel-like structure. The crosslinking process also affects the structural and gel properties of the starch, including the firmness of the gel, pasting temperature, gelatinization enthalpy, and crystallinity. The gel formation is a result of the interaction between the starch and CaCl2, which leads to the organization of crystallites in the starch granules and the formation of ordered structures within the gel. The gel properties can be regulated by adjusting the concentration of CaCl2, allowing for the development of low-viscosity starch gels with controlled stability under shear during heating.

What is the maximum concentration of calcium chloride that can be used to crosslink alginate?2 answersThe maximum concentration of calcium chloride that can be used to crosslink alginate is not explicitly mentioned in the abstracts provided. However, the abstract by Wang Chunhong et al. states that the calcium chloride is used to cross-link the sodium alginate solution, improving the spinnability of the sodium alginate. Additionally, the abstract by Warsha Barde mentions that alginate is crosslinked using calcium chloride to obtain tubular structures in the macrometer range. These abstracts suggest that calcium chloride is used for crosslinking alginate, but the specific maximum concentration is not mentioned.

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