How is phagocytosis transcriptionally regulated in macrophages?
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Phagocytosis in macrophages is transcriptionally regulated through various mechanisms. Activation of transcription factors like TFEB and TFE3 is crucial during bacterial phagocytosis, linking phagocytosis with gene expression changes . Additionally, the presence of all-trans retinoic acid enhances myelin phagocytosis by inducing tissue transglutaminase-2, without affecting the expression of phagocytic receptors . Furthermore, phagocytic TAMs exhibit a distinct gene expression profile associated with oxidative phosphorylation and metabolic changes, impacting tumor-associated macrophage phenotypes . These findings underscore the complexity of transcriptional regulation in macrophages during phagocytosis, involving factors like TFEB, metabolic genes, and retinoic acid signaling.
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36 Citations | Transcriptional factors regulate phagocytosis in macrophages, with diverse subsets influenced by tissue of residence and ontogeny, highlighting the complexity of mononuclear phagocyte development. |
| Phagocytosis in macrophages is transcriptionally regulated by all-trans retinoic acid (RA) through induction of tissue transglutaminase-2, without altering expression of specific phagocytic receptor genes. | |
| Phagocytosis in macrophages is transcriptionally regulated by a novel PHOX/CD38/MCOLN1/TFEB axis, involving oxidative burst, NAADP generation, Ca2+ efflux, and TFEB-dependent cytokine expression. | |
2 Citations | Phagocytosis in tumor-associated macrophages (TAMs) leads to upregulation of antigen presentation and metabolic genes, particularly oxidative phosphorylation (OXPHOS), influencing immune suppression and tumor promotion. |
| Phagocytosis in macrophages is regulated transcriptionally through changes in molecular expression and post-translational modifications, as discussed in the paper. |
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