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How much research has been done on sustained-release of poorly water-soluble drugs?

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A significant amount of research has been conducted on the sustained release of poorly water-soluble drugs. Various techniques have been explored to enhance the solubility and controlled release of such drugs, including solid dispersion, micronization, salt formation, inclusion complexation, nano-suspension, supercritical processing, cryogenic technologies, and the development of core-shell hydrogels. These approaches aim to overcome the challenges posed by the poor aqueous solubility of drugs, ensuring sustained and controlled release over an extended period. The utilization of natural ingredients like palygorskite and chitosan in combination with model drugs such as ethambutol has shown promising results in achieving prolonged release profiles and improved stability of the administered product.

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Journal Article•DOI Review on: Solubility Enhancement of Poorly Water Soluble Drugs M. H. Markad, SD Mankar - Show less +1 more 10 Aug 2022	Research extensively covers enhancing solubility of poorly water-soluble drugs through techniques like solid dispersion, micronization, salt formation, and novel approaches such as nano-suspension, supercritical processing, and cryogenic technologies.
Open access•Journal Article•DOI Customized Hydrogel for Sustained Release of Highly Water-Soluble Drugs Xin Jin, Chengxiong Wei, Chengwei Wu, Wei Zhang - Show less +3 more 01 Mar 2022-ACS Omega 1 Citations	Not addressed in the paper.
Book Chapter•DOI Injectable Formulations of Poorly Water-Soluble Drugs 01 Jan 2022	Research on sustained release of poorly water-soluble drugs is addressed in the paper, highlighting various formulation approaches for enhancing solubility in injectable drug delivery systems.
Open access•Journal Article•DOI Solubilization and Controlled Release Strategy of Poorly Water-Soluble Drugs Mayra Álvarez Peña 01 Nov 2022-Pharmaceuticals	Research on solubilization and controlled release of poorly water-soluble drugs is significant in pharmaceutical development, indicating a substantial focus on sustained-release strategies for such drugs.

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