How organic chemistry contributes to the development of new drugs and medicines,providing illustrative examples?
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Organic chemistry plays a crucial role in the development of new drugs and medicines. It provides the necessary tools and strategies for synthesizing molecules that are essential for drug discovery and development . By utilizing organic reactions and chemical reactions catalyzed by target enzymes, medicinal chemists can identify potential drug candidates . Modern synthetic methods, such as catalytic processes and palladium catalyzed cross-coupling, have been instrumental in the synthesis of innovative drugs like sofosbuvir and rivaroxaban . However, there are still challenges in organic synthesis that need to be addressed, such as the need for new reactions enabling late-stage functionalization and stereoselectively substituted aliphatic heterocyclic ring synthesis . Collaboration between academic and industrial chemists is crucial in overcoming these challenges and accelerating the drug discovery process .
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| Organic chemistry contributes to drug development through the construction of focused libraries using organic reactions and the rational design of enzyme inhibitors based on chemical reactions catalyzed by the target enzyme. Examples include histone deacetylase inhibitors and lysine-specific demethylase 1 inhibitors. | |
6 Citations | Organic chemistry contributes to the development of new drugs by providing synthetic methods and strategies to prepare molecules for key data. Examples include ABBV-2222 for cystic fibrosis and foslevodopa/foscarbidopa for Parkinson's disease. |
9 Citations | Organic chemistry contributes to the development of new drugs by designing chemical reactions that give functionalized bioactive heterocyclic motifs with pharmacophoric properties. |
761 Citations | The paper discusses the challenges in synthetic organic chemistry for drug discovery, including the need for new reactions and technologies. It does not provide specific illustrative examples of how organic chemistry contributes to the development of new drugs and medicines. |
| The paper discusses the application and progress of modern synthetic methods in the discovery of innovative drugs, providing examples such as sofosbuvir, rivaroxaban, enzalutamide, canagliflozin, and tofacitinib. |
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