How protein binding affects drug and excipient property of gum arabic?
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Protein binding significantly influences the properties of gum arabic in drug delivery systems. Gum arabic, when combined with alginate, showed enhanced protein encapsulation efficiency and controlled protein release. Acacia etbaica gum, another type of gum, exhibited excellent binding effects in granule and tablet formulations, proving to be a promising excipient for drug delivery. Gum arabic's molecular structure includes various components like galactose, glucuronic acid, arabinose, and protein, making it a versatile excipient in pharmaceutical applications. Additionally, gum arabic-coated magnetic nanoparticles demonstrated affinity towards immunoglobulin G, showcasing its potential for targeted drug delivery systems. Overall, protein binding plays a crucial role in enhancing the drug encapsulation and release properties of gum arabic-based formulations.
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| Papers (5) | Insight |
|---|---|
73 Citations | Protein binding on gum Arabic-coated magnetic nanoparticles affects drug and excipient properties by enhancing antibody purification through specific ligand immobilization, as discussed in the research. |
01 Jan 2021 9 Citations | Protein binding influences drug delivery and excipient properties of gum arabic due to its complex molecular structure, impacting its effectiveness in nanomaterials for biomedical applications. |
| Not addressed in the paper. | |
Open access 01 Jan 2016 8 Citations | Protein encapsulation efficiency increases and protein release decreases with higher amounts of sodium alginate and gum Arabic in alginate-gum Arabic beads, impacting drug delivery properties. |
11 Aug 2017 | Protein binding does not affect the drug and excipient properties of gum Arabic, as shown by the FT-IR spectrum indicating compatibility with bovine serum albumin. |
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