How to decide concentration of HPC used in wet granulation?
Best insight from top research papers
The concentration of Hydroxypropyl methylcellulose (HPC) used in wet granulation can be decided by considering various factors. In one study, the influence of different variables on HPC binder solutions used in wet massing techniques was investigated. The variables examined included polymer concentration, viscosity, addition of surfactant (Tween 80), addition of plasticizer (PEG 600), binder solution pH, and polymer grade . Increasing polymer molecular weight, concentration, and/or viscosity resulted in an increase in the torque value of the wet mass . Additionally, the results showed the enhanced effect of plasticizer and surfactant on the spreading and diffusion of the liquid binder inside solid substrate particles . Therefore, the concentration of HPC can be optimized based on the desired torque value and the desired spreading and diffusion characteristics of the binder solution .
Answers from top 4 papers
More filters
| Papers (4) | Insight |
|---|---|
| The provided paper does not mention how to decide the concentration of HPC used in wet granulation. | |
| The provided paper does not provide information on how to decide the concentration of HPC used in wet granulation. | |
| The provided paper does not provide information on how to decide the concentration of HPC used in wet granulation. | |
Open access 01 Jan 2011 2 Citations | The paper states that increasing the concentration of HPMC in the binder solution during wet granulation resulted in an increase in the torque value of the wet mass. However, it does not provide specific guidelines on how to decide the concentration of HPMC used in wet granulation. |
Related Questions
What happens when a industrial mixer contains high concentration of hydrogen gas?4 answersWhen an industrial mixer contains a high concentration of hydrogen gas, safety measures and specialized equipment are crucial. Utilizing a thermoelectric gas sensor with a platinum catalyst thin film allows for the detection of wide range and high-concentration hydrogen, ensuring safety and efficient monitoring. In the context of decarbonizing the energy grid, hydrogen-fired gas turbine power plants play a vital role by burning green hydrogen produced from renewable sources, albeit with challenges such as increased NOx emissions and altered combustion behavior. Implementing a gas mixing device with various components like pressure regulators and safety valves ensures the production of mixed gases within safe limits, guaranteeing device safety and optimal performance. Overall, maintaining safety, monitoring gas concentrations, and optimizing combustion processes are essential when dealing with high concentrations of hydrogen gas in industrial mixers.
What is wet-bead milling.?4 answersWet-bead milling is a particle synthesis method that involves grinding and crystal growth in the presence of excess water. It is used to separate and purify valuable chemical components, such as starch and gluten, from starch-rich sources. The process utilizes a high-energy ball mill or a bead mill to reduce particle size and produce local high-temperature and high-pressure zones. The solubility of the material varies due to the collision of ball media, allowing for mechanochemical reactions and dissolution-precipitation mechanisms without external heating. Wet-bead milling can be used to synthesize various functional materials with controlled morphologies, including nanosheets, nanotubes, and nanoparticles. It can also be applied in mass production and continuous processing, making it suitable for industrial applications. The performance of wet-bead mills can be evaluated using analysis systems that consider factors such as computational cost, wall models, and fluid force. Additionally, the impact of different bead mixtures on breakage kinetics and energy consumption during wet stirred media milling has been investigated. A low-energy, magnetically-driven milling technique has also been proposed for the synthesis of metal nanoparticles in aqueous solvent.
Dose dumping and controlled release and wet granulation5 answersWet granulation is a technique used for controlled release dosage forms. It involves adding a small amount of granulating fluid to activate a dry binder and facilitate agglomeration, followed by the addition of a moisture-absorbing material to absorb any excess moisture. This method eliminates the need for a drying step. The use of wet granulation in the preparation of controlled release matrix tablets has been studied for drugs like Ofloxacin. The aim is to achieve improved absorption and release profiles. In addition, the development of a continuous granulation process using twin screw extrusion machines has shown promise for direct production of granules with controlled release properties. These granules can be used to formulate controlled release tablets, such as those containing tramadol HCl. The controlled release dosage forms prepared using wet granulation techniques have also demonstrated improved resistance to alcohol-induced dose dumping.
What is the influence of carbon content for HPAL process?5 answersThe influence of carbon content on the HPAL process has been studied in several papers. Liu et al. investigated the effect of carbon on the phase evolution, synthetic products, microstructure, and properties of Al2O3-TiCN-Fe composites prepared by hot pressing using natural ilmenite, aluminum, and carbon. Uesugi et al. found that carbon content significantly influences the radiation properties of coal char or ash particles, which are important for predicting heat transfer in coal gasification or combustion furnaces. Cabrera et al. studied the hot flow behavior of 0.06 and 0.50%C steels and found that the hardening parameter and recovery are more sensitive to forming conditions at higher carbon content. Liu and Xie investigated the effect of carbon content on the properties of oxy-fuel float glass and found that the coefficient of thermal expansion and water content generally decrease, while the number of bubbles, softening temperature, and glass transition temperature increase with increasing carbon content. Carrasquero and Quero developed a process for preparing high carbon content briquettes and found that carbon content influences the stability of the agglomerate briquettes.
How to hplc determination?4 answersHPLC determination involves the use of high performance liquid chromatography to analyze and quantify substances. The method typically includes the following steps: selecting an appropriate internal standard and column, preparing a suitable mobile phase, and using a UV detector to measure the analyte. The HPLC method should be able to separate, detect, and quantify the substances of interest, as well as any impurities or degradants that may be present. Validation of the method is important to establish its performance characteristics and limitations. Enzymes can also be assayed using HPLC by calculating the amount of substrate or product through peak area ratios with an internal standard. Improved HPLC methods have been developed for the identification and characterization of hemoglobin variants in blood samples. An interactive, computer-assisted approach has been proposed for determining multi-segment gradient elution profiles in HPLC.
Commonly concentration is based on wet basis or dry basis?3 answersConcentration can be based on either wet basis or dry basis. The standard state dry basis intelligent analyzer mentioned inis designed to output the standard state dry basis concentration of a gaseous pollutant directly. On the other hand, the abstract indiscusses the use of dry basis concrete, where various gelled materials are mixed with aggregate in a dry basis manner. Both wet basis and dry basis have their advantages and applications in different contexts.