Is oral hyaluronic acid supplement good for dry eye?5 answersOral hyaluronic acid (HA) supplementation has shown promising results in improving dry eye disease (DED). Studies have demonstrated that a combined supplement of both oral and topical HA can more effectively enhance corneal epithelial wound healing and alleviate related symptoms compared to using topical HA alone. Research has also highlighted the safety and efficacy of artificial tears containing HA in treating DED, with concentrations ranging from 0.1% to 0.4% and showing improvements in both signs and symptoms of the condition. Furthermore, oral supplementation of HA has been found to positively impact skin aging by increasing hydration and reducing expression lines, indicating its potential as a treatment for preventing skin aging. Overall, oral HA intake has shown benefits in improving skin condition, including reducing wrinkles and enhancing skin elasticity.
Does hyaluronic acid mat the skin?4 answersHyaluronic acid (HA) plays a significant role in skin health and regeneration. It is a major component of the extracellular matrix (ECM) of the skin, contributing to moisture retention and anti-aging effects. HA has been studied for its potential in wound healing and tissue regeneration. Moreover, HA-based hydrogels have been developed for skin wound healing, utilizing various crosslinking strategies to enhance their properties. Additionally, HA has been incorporated into 3D-printed hydrogels for tissue engineering, showing enhanced cell viability and potential for constructing artificial skin. Therefore, HA, whether extracted from natural sources or synthesized, demonstrates promising applications in skincare, wound healing, and tissue regeneration, making it a valuable component for maintaining skin health and combating aging effects.
What are the benefits of hyaluronic acid for the skin?4 answersHyaluronic acid (HA) has several benefits for the skin. It has a favorable moisturizing property and can enhance the skin's permeability to drugs. HA is commonly used as a dermal filler to improve wrinkles and volume loss by filling and hydrating the injected area. It is a naturally occurring component of the skin and has a low risk of immunologic or allergic reactions when injected. HA can also stimulate collagen synthesis and fibroblast activity, leading to a longer duration of its effects. Topical use of HA in cosmeceuticals has been shown to improve skin hydration and rejuvenation. HA-based cosmeceuticals are well-tolerated and effective in improving skin hydration and reducing wrinkles. HA also has bioactive applications in various sectors of biomedicine due to its biocompatibility and non-toxicity. Exogenous HA can be used in aesthetic and dermatological aspects to enhance skin rejuvenation and overall health.
What is hyaluronic acid ?5 answersHyaluronic acid (HA) is a naturally occurring polysaccharide found in the human body. It is a component of the extracellular matrix of connective tissues and has important roles in regulating interactions between growth factors, maintaining tissue volume, and providing lubrication. HA is also used in cosmetology and aesthetic medicine due to its ability to improve the quality and vitality of the skin. Exogenous HA has been studied for its potential applications in the treatment of inflammatory diseases, providing pain relief and exhibiting desirable biocompatibility and biodegradability. The production of HA can be achieved through the use of genetically modified strains of E. coli, with factors such as media composition, aeration, and agitation impacting the production yield. Different forms of HA, such as low-molecular-weight HAs and hyaluronan oligosaccharides, have unique biological properties and find applications in medicine.
What are the effects of normal synovial fluid metabolites on hyaluronic acid?5 answersNormal synovial fluid metabolites have various effects on hyaluronic acid (HA). Both peripheral blood monocyte and rheumatoid synovial fluid macrophage conditioned media stimulate HA synthesis in synovial fibroblasts, leading to increased production of high molecular weight HA. Age and sex influence the metabolism of HA in knee joint tissues, with concentrations of HA and chondroitin sulfates (CS) showing a negative correlation with age. Women have lower concentrations of CS compared to men. All-atom molecular dynamics simulations reveal that direct hydrogen bonds and water-mediated interactions with lipid headgroups play a key role in the binding of HA to lipid bilayers. The degree of charge redistribution increases with the molecular weight of HA, leading to enhanced tribological properties. The viscosity of synovial fluid, which depends on the concentration and polymerization of HA, is also influenced by its association with proteins.
How to prepare 1 molar solution of hyaluronic acid?2 answersTo prepare a 1 molar solution of hyaluronic acid, the following methods can be used. Ruan Chunxue et al. developed a method that involves converting sodium hyaluronate solution into hyaluronic acid and free sodium ions, removing low-molecular inorganic salt, precipitating and separating the hyaluronic acid using emulsification, dehydrating the solid using organic solvent mixed with water, and finally obtaining the hyaluronic acid product through centrifugal separation and vacuum drying. Another method, proposed by Yan Lidong, involves preparing a hyaluronic acid stock solution comprising water, 1,2-pentanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, hydroxyethyl cellulose, dipropylene glycol, phenoxyethanol, sodium citrate, citric acid, a hydrolyzed collagen mixture, and a butylene glycol mixture. These methods provide different approaches to prepare hyaluronic acid solutions, each with its own advantages and characteristics.