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Is coronavirus RNA infectious? 

RNA
Viral replication
Virus
Coronavirus
RNA virus

Answers from top 10 papers

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Papers (10)Insight
Open access•Journal Article•DOI
Can the novel coronavirus be transmitted via RNAs without protein capsids
Zhongneng Xu
30 Sep 2020-Journal of Infection in Developing Countries
4 Citations
I speculate that SARS-CoV-2 RNAs are infectious based on the following rationale and offer a putative mechanism: RNA is the most important biomolecule of the novel coronavirus for expression and replication, free RNA strands of SARS-CoV-2 have the potential to remain suspended in the air and retain their biological activity, and some exogenous RNAs can enter the host cell after contact.
Open access•Journal Article•DOI
Combining mathematics and empirical data to predict emergence of RNA viruses that differ in reservoir use
C. Brandon Ogbunugafor, Sanjay Basu, Nadya M. Morales, Paul E. Turner 
27 Jun 2010-Philosophical Transactions of the Royal Society B
10 Citations
RNA viruses may be particularly capable of contributing to the increasing biomedical problem of infectious disease emergence.
Open access•Posted Content•DOI
SARS-CoV-2 genomic and subgenomic RNAs in diagnostic samples are not an indicator of active replication
Soren Alexandersen, Soren Alexandersen, Soren Alexandersen, Anthony Chamings, Anthony Chamings, Tarka Raj Bhatta, Tarka Raj Bhatta 
16 Aug 2020-medRxiv
22 Citations
Overall, we present evidence that subgenomic RNAs may not be an indicator of active coronavirus replication/infection, but that these RNAs, similar to the virus genome RNA, may be rather stable, and thus detectable for an extended period, most likely due to their close association with cellular membranes.
Open access•Posted Content•DOI
A unifying structural and functional model of the coronavirus replication organelle: tracking down RNA synthesis
Eric J. Snijder, Ronald W. A. L. Limpens, Adriaan H. de Wilde, Anja W. M. de Jong, Jessika C. Zevenhoven-Dobbe, Helena J. Maier, Frank G. A. Faas, Abraham J. Koster, Montserrat Bárcena 
24 Mar 2020-bioRxiv
44 Citations
Our results provide a unifying model of the CoV RO and clearly establish DMVs as the central hub for viral RNA synthesis and a potential drug target in coronavirus infection.
Open access•Journal Article•DOI
Genome of porcine transmissible gastroenteritis virus.
David A. Brian, D. E. Dennis, James S. Guy 
01 May 1980-Journal of Virology
53 Citations
This coronavirus can therefore be characterized as a positive-strand RNA virus.
Open access•Journal Article•DOI
Presence of infectious polyadenylated RNA in the coronavirus avian bronchitis virus
Gerald Schochetman, Roy H. Stevens, Robert W. Simpson 
01 Apr 1977-Virology
88 Citations
These findings, together with the observation that IBV virions do not exhibit detectable transcriptase activity, support the conclusion that the genome of this coronavirus acts directly as a messenger RNA in eukaryotic cells.
Open access•Journal Article•DOI
Mechanism of coronavirus transcription: duration of primary transcription initiation activity and effects of subgenomic RNA transcription on RNA replication.
Yong Seok Jeong, Shinji Makino 
01 Jun 1992-Journal of Virology
57 Citations
Therefore, the previously proposed hypothesis that coronavirus, subgenomic RNA synthesis may inhibit the replication of genomic RNA by competing for a limited amount of virus-derived factors seems unlikely.
Open access•Journal Article•DOI
The making of infectious viral RNA: No size limit in sight
Michael M. C. Lai
09 May 2000-Proceedings of the National Academy of Sciences of the United States of America
26 Citations
Because coronavirus contains the longest viral RNA genome by far (and is probably one of the longest stable RNAs in nature), this approach seems to pave the way for the reverse genetics studies for all RNA viruses.
Open access•Book Chapter•DOI
Viral and cellular proteins involved in coronavirus replication.
S. T. Shi, Michael M. C. Lai 
01 Jan 2005-Current Topics in Microbiology and Immunology
95 Citations
Like many other RNA viruses, coronavirus may subvert these cellular proteins from cellular RNA processing or translation machineries to play a role in viral replication.
Open access•Posted Content•DOI
Comparative analysis of coronavirus genomic RNA structure reveals conservation in SARS-like coronaviruses
Wes Sanders, Ethan J. Fritch, Emily A Madden, Rachel L. Graham, Heather A. Vincent, Mark T. Heise, Ralph S. Baric, Nathaniel J. Moorman 
16 Jun 2020-bioRxiv
34 Citations
We find that highly stable RNA structures are pervasive throughout coronavirus genomes, and are conserved between the SARS-like CoV.

Related Questions

Coronaviruses are RNA viruses that infect humans and animals ?5 answersCoronaviruses (CoVs) are enveloped, plus-strand RNA viruses with the largest RNA genomes, infecting birds and mammals, causing various diseases in both humans and animals. Human coronaviruses (HCoVs) were first identified in the mid-1960s, causing enteric or respiratory infections, with recent emergences like SARS-CoV-2 leading to the ongoing pandemic. CoVs are classified into different genera based on their hosts, with Alphacoronaviruses and Betacoronaviruses originating mainly from bats, while Gammacoronaviruses and Deltacoronaviruses are sourced from birds. These viruses can cause a range of illnesses in animals, from gastrointestinal infections to respiratory diseases, with some strains being highly pathogenic and leading to outbreaks with high mortality rates in humans.
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