J
Jessika C. Zevenhoven-Dobbe
Researcher at Leiden University Medical Center
Publications - 39
Citations - 5491
Jessika C. Zevenhoven-Dobbe is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Coronavirus & RNA. The author has an hindex of 23, co-authored 39 publications receiving 4280 citations.
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Journal ArticleDOI
SARS-Coronavirus Replication Is Supported by a Reticulovesicular Network of Modified Endoplasmic Reticulum
Kèvin Knoops,Marjolein Kikkert,Sjoerd H. E. van den Worm,Jessika C. Zevenhoven-Dobbe,Yvonne van der Meer,Abraham J. Koster,A. Mieke Mommaas,Eric J. Snijder +7 more
TL;DR: The ultrastructural description of this “replication network” will aid to further dissect the early stages of the coronavirus life cycle and its virus-host interactions.
Journal ArticleDOI
Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture
Adriaan H. de Wilde,Dirk Jochmans,Clara C. Posthuma,Jessika C. Zevenhoven-Dobbe,Stefan van Nieuwkoop,Theo M. Bestebroer,Bernadette G. van den Hoogen,Johan Neyts,Eric J. Snijder +8 more
TL;DR: Four compounds are identified inhibiting MERS-CoV replication in the low-micromolar range (50% effective concentrations [EC50s], 3 to 8 μM) and may offer a starting point for treatment of patients infected with zoonotic coronavirus infections.
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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities
Lorenzo Subissi,Clara C. Posthuma,Axelle Collet,Jessika C. Zevenhoven-Dobbe,Alexander E. Gorbalenya,Etienne Decroly,Eric J. Snijder,Bruno Canard,Isabelle Imbert +8 more
TL;DR: This study reveals that the SARS-coronavirus RNA polymerase (nsp12) needs to associate with nsp7 and nsp8 to activate its capability to replicate long RNA and defines the core of an RNA-synthesizing machinery that is unique in the RNA virus world and includes several key targets for antiviral drug development.
Journal ArticleDOI
Ultrastructure and Origin of Membrane Vesicles Associated with the Severe Acute Respiratory Syndrome Coronavirus Replication Complex
Eric J. Snijder,Yvonne van der Meer,Jessika C. Zevenhoven-Dobbe,Jos J. M. Onderwater,Jannes van der Meulen,Henk K. Koerten,A. Mieke Mommaas +6 more
TL;DR: In this article, a panel of replicase-specific antisera was used to analyze the earlier stages of severe acute respiratory syndrome coronavirus (SARS-CoV) infection in Vero E6 cells.
Journal ArticleDOI
SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology.
Natacha S. Ogando,Tim J. Dalebout,Jessika C. Zevenhoven-Dobbe,Ronald W. A. L. Limpens,Yvonne van der Meer,Leon Caly,Julian Druce,Jutte J.C. de Vries,Marjolein Kikkert,Montserrat Bárcena,Igor A. Sidorov,Eric J. Snijder +11 more
TL;DR: The sensitivity of the two viruses to three established inhibitors of coronavirus replication is very similar, but that SARS-CoV-2 infection was substantially more sensitive to pre-treatment of cells with pegylated interferon alpha.