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Is vitamin K anti-inflammatory?

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Vitamin K has been shown to have anti-inflammatory properties and can suppress signaling pathways involved in inflammation . It can also inhibit the activation of the NLRP3 inflammasome, a complex involved in the pathogenesis of inflammatory diseases . Various forms of exogenous vitamin K, such as K1, K3, and MK-5, have demonstrated anti-inflammatory effects in macrophages . Additionally, vitamin K can act as an antioxidant, protecting against the generation of reactive oxidative species . Clinical evidence suggests that a high vitamin K status can have a protective role in age-related diseases associated with inflammation and mineralization processes . However, a study on rheumatoid arthritis patients found that vitamin K1 supplementation did not significantly reduce inflammation or disease severity . Overall, while vitamin K has shown potential as an anti-inflammatory agent, further research is needed to fully understand its mechanisms and effectiveness in different inflammatory conditions.

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Open access•Journal Article•DOI Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies Dina C. Simes, Carla Viegas, Nuna Araújo, Catarina Marreiros - Show less +3 more 25 Aug 2019-International Journal of Molecular Sciences 45 Citations	Yes, according to the paper, vitamin K has been shown to act as an anti-inflammatory by suppressing nuclear factor κB (NF-κB) signal transduction.
Open access•Journal Article•DOI Exogenous Vitamins K Exert Anti-Inflammatory Effects Dissociated from Their Role as Substrates for Synthesis of Endogenous MK-4 in Murine Macrophages Cell Line Anna Kieronska-Rudek, Agnieszka Kij, Patrycja Kaczara, Anna Tworzydlo, Marek Napiorkowski, Katarzyna Sidoryk, Stefan Chlopicki - Show less +6 more 22 Jun 2021-Cells 3 Citations	Yes, according to the paper, vitamins K exert anti-inflammatory effects.
Open access The Anti-Inflammatory Effect of Vitamin K in Aging Zainab Nazar Hasan Anber 22 Apr 2021	Yes, vitamin K is recognized to play an anti-inflammatory role by suppressing signaling pathways such as the nuclear factor IoB (NF-IoB) pathway.
Journal Article•DOI Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome Xicui Zheng, Yingting Hou, Hongbin He, Yun Chen, Rongbin Zhou, Xiaqiong Wang, Tao Gong, Wei Jiang - Show less +7 more 01 Oct 2021-Cellular & Molecular Immunology 19 Citations	The paper states that previous studies have indicated that vitamin K may have anti-inflammatory properties, but the underlying mechanisms of its anti-inflammatory effects remain unclear.

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