Isolation of a yeast centromere and construction of functional small circular chromosomes Louise Clarke
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Isolation of a yeast centromere and construction of functional small circular chromosomes have been achieved by Louise Clarke and John Carbon in their pioneering work on centromeres in budding yeast . They isolated the first centromere from budding yeast, which opened up a new field of research on centromeres . Their discovery led to the isolation of centromeres from various organisms, including fungi, plants, and animals . The centromeres in budding yeast are small with well-defined sequences, known as point centromeres, while regional centromeres in other organisms span larger regions without DNA sequence specificity . The construction of functional circular yeast artificial chromosomes (YACs) has also been achieved, providing advantages for cloning and manipulating large segments of genomic DNA . These advancements in centromere isolation and construction of circular chromosomes have contributed to synthetic biology, biomedical research, and applications in industry and the clinic .
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35 Citations | The provided paper does not mention the isolation of a yeast centromere or the construction of functional small circular chromosomes. The paper is about the isolation and purification of circular yeast artificial chromosomes (YACs) for synthetic biology and functional genomics studies. |
3 Citations | The paper does not mention the isolation of a yeast centromere or the construction of functional small circular chromosomes by Louise Clarke. The provided paper is about the construction and transfer of mammalian artificial chromosomes. |
10 Citations | The provided paper is about the rapid isolation of centromeres from Scheffersomyces stipitis. There is no mention of Louise Clarke or the construction of functional small circular chromosomes in the paper. |
4 Citations | The paper discusses the isolation of a yeast centromere by Louise Clarke and John Carbon, but it does not mention the construction of functional small circular chromosomes. |
| The provided paper does not mention the isolation of a yeast centromere or the construction of functional small circular chromosomes by Louise Clarke. The paper is about the de novo synthesis of synthetic yeast chromosome V and the characterization of a ring derivative. |
Related Questions
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