J
Joel S. Bader
Researcher at Johns Hopkins University
Publications - 209
Citations - 27368
Joel S. Bader is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 62, co-authored 199 publications receiving 25111 citations. Previous affiliations of Joel S. Bader include New York University & Columbia University.
Papers
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Journal ArticleDOI
Genome sequencing in microfabricated high-density picolitre reactors
Marcel Margulies,Michael Egholm,William E. Altman,Said Attiya,Joel S. Bader,Lisa A. Bemben,Jan Berka,Michael S. Braverman,Yi-Ju Chen,Zhoutao Chen,Scott Dewell,Lei Du,J. M. Fierro,Xavier V. Gomes,Brian C. Godwin,Wen He,Scott Edward Helgesen,Chun Heen Ho,Gerard P. Irzyk,Szilveszter C. Jando,Maria L. I. Alenquer,Thomas P. Jarvie,Kshama B. Jirage,Jong-Bum Kim,James R. Knight,Janna R. Lanza,John H. Leamon,Steven Lefkowitz,Ming Lei,Jing Li,Kenton Lohman,Hong Lu,Vinod Makhijani,Keith Mcdade,Michael P. McKenna,Eugene W. Myers,Elizabeth Nickerson,John Nobile,Ramona Plant,Bernard P. Puc,Michael T. Ronan,George T. Roth,Gary J. Sarkis,Jan Fredrik Simons,John Simpson,Maithreyan Srinivasan,Karrie R. Tartaro,Alexander Tomasz,Kari A. Vogt,Greg A. Volkmer,Shally H. Wang,Yong Wang,Michael P. Weiner,Pengguang Yu,Richard F. Begley,Jonathan M. Rothberg +55 more
TL;DR: A scalable, highly parallel sequencing system with raw throughput significantly greater than that of state-of-the-art capillary electrophoresis instruments with 96% coverage at 99.96% accuracy in one run of the machine is described.
Journal ArticleDOI
A Protein Interaction Map of Drosophila melanogaster
Loic Giot,Joel S. Bader,Cory Brouwer,Amitabha Chaudhuri,B. Kuang,Ying Li,Y. L. Hao,C. E. Ooi,Brian C. Godwin,E. Vitols,G. Vijayadamodar,Pascale Pochart,H. Machineni,M. Welsh,Yong Kong,B. Zerhusen,Rachel D. Malcolm,Z. Varrone,A. Collis,M. Minto,S. Burgess,L. McDaniel,E. Stimpson,F. Spriggs,Julia Williams,K. Neurath,N. Ioime,M. Agee,E. Voss,K. Furtak,R. Renzulli,N. Aanensen,S. Carrolla,E. Bickelhaupt,Y. Lazovatsky,A. DaSilva,Jinhui Zhong,Clement A. Stanyon,Russell L. Finley,Kevin P. White,Michael S. Braverman,Thomas P. Jarvie,Steven Allen Gold,M. Leach,James R. Knight,Richard A. Shimkets,Michael P. McKenna,John Chant,Jonathan M. Rothberg +48 more
TL;DR: This map serves as a starting point for a systems biology modeling of multicellular organisms, including humans, and recapitulated known pathways, extended pathways, and uncovered previously unknown pathway components.
Patent
Method of sequencing a nucleic acid
Jonathan M. Rothberg,Joel S. Bader,Scott Dewell,Keith Mcdade,John Simpson,Jan Berka,Christopher M. Colangelo +6 more
TL;DR: In this article, methods and apparatuses for sequencing a nucleic acid are presented. But their methods require a large number of independent sequencing reactions to be arrayed in parallel, permitting simultaneous sequencing of a very large number (>10,000) of different oligonucleotides.
Journal ArticleDOI
DNA Pooling: a tool for large-scale association studies
TL;DR: Recent developments in quantitative genotyping assays and in the design and analysis of pooling studies are discussed.
Journal ArticleDOI
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.
Kevin J. Cheung,Veena Padmanaban,Vanesa L. Silvestri,Koen Schipper,Joshua D. Cohen,Amanda N. Fairchild,Michael A. Gorin,James E. Verdone,Kenneth J. Pienta,Joel S. Bader,Andrew J. Ewald +10 more
TL;DR: K14 is revealed as a key regulator of metastasis and the concept that K14+ epithelial tumor cell clusters disseminate collectively to colonize distant organs is established, to enable novel prognostics and therapies to improve patient outcomes.