Mechanisms by which nitrate may influence oral health?
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Nitrate can influence oral health through various mechanisms. Oral bacteria have the ability to reduce nitrate to nitrite, which can then be further reduced to nitric oxide (NO) in the body. This nitrate-nitrite-NO pathway has been shown to have antimicrobial properties, inhibiting bacteria involved in periodontal diseases . Nitrate has also been found to increase resilience against salivary acidification, potentially preventing the development of caries . Additionally, nitrate can modulate the composition and activity of the oral microbiota, increasing the abundance of health-associated bacteria such as Rothia and Neisseria, while reducing the levels of caries-associated and periodontitis-associated genera . The presence of nitrate in the oral cavity can also act as a reservoir of NO, performing various NO-like bioactivities that can benefit oral health . However, further robust clinical studies are needed to confirm the potential benefits of nitrate reduction on oral health .
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53 Citations | The paper discusses the potential beneficial effects of nitrate on oral health, including lactate consumption and ammonia-mediated pH buffering. |
| The paper discusses the role of dietary nitrate in maintaining oral health by promoting the establishment of a non-cariogenic oral microbiome and microbial homeostasis. It also mentions the potential therapeutic and preventive prospects of a nitrate-rich diet in dental research. However, it does not provide specific mechanisms by which nitrate may influence oral health. | |
20 Citations | The paper discusses several mechanisms by which nitrate may influence oral health, including the reduction of nitrite to nitric oxide by oral bacteria, which has antimicrobial properties, and the increase in resilience against salivary acidification, preventing caries development. |
26 May 2022 | The paper does not specifically mention the mechanisms by which nitrate may influence oral health. The paper primarily focuses on the protective roles of inorganic nitrate in health and diseases, including its effects on the salivary glands, microbial homeostasis, exercise performance, digestive system, blood pressure, and tumor treatment. |
Related Questions
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Does nitrate affect physical performance in human?5 answersDietary nitrate supplementation has been shown to improve physical performance in humans, particularly in non-athletes during long-duration open-ended tests. Acute and chronic nitrate supplementation has been found to enhance endurance exercise performance in both trained individuals and athletes. Nitrate supplementation has been shown to reduce the oxygen cost of submaximal exercise, improve muscle efficiency, and increase muscle power and sprint exercise performance. The recommended range for nitrate supplementation is approximately 5-16.8 mmol (~300-1041 mg) taken 2-3 hours before exercise. Nitrate needs can also be met through the consumption of nitrate-rich foods, such as leafy and root vegetables, but dietary supplements may provide a more convenient and accurate way to cover an athlete's nitrate needs. Future research should focus on the potential beneficial effects of nitrate supplementation on brain function, the negative impacts of chronic nitrate supplementation, and the effectiveness of nitrate supplementation on strength and high-intensity intermittent exercise.
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