What are kinases?
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Kinases are a family of proteins that catalyze phosphorylation reactions by transferring the terminal γ-phosphate of ATP onto hydroxyl groups of various proteins, lipids, or carbohydrates . They function as molecular switches, regulating essential cellular activities such as cell proliferation . Dysfunctional kinases are implicated in several types of cancers, making them important drug targets . The human genome contains 518 protein kinase genes, with 478 belonging to the classical protein kinase family and 40 being atypical protein kinases . Kinases play a pivotal role in phosphorylation-mediated signaling networks in living cells, and their identification is key in understanding global signaling modulation . However, only a small percentage of known phosphosites are assigned to a kinase, prompting bioinformatics efforts to predict responsible kinases .
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| Kinases are enzymes that catalyze the phosphorylation of specific amino acids in proteins, leading to conformational changes and activation or deactivation of the proteins. | |
| Kinases are enzymes that catalyze protein phosphorylation. The paper mentions that the human genome contains 518 protein kinase genes. | |
| Kinases are a family of proteins that function as molecular switches, regulating essential cellular activities such as cell proliferation. (Answer from the paper) | |
| Kinases are a large class of proteins that catalyze phosphorylation reactions by transferring the terminal γ-phosphate of ATP onto various molecules such as proteins, lipids, or carbohydrates. |
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