What are significant applications of chalcones?
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Chalcones have significant applications in various fields including medicinal chemistry, synthetic and pharmaceutical chemistry, and coordination chemistry . They have been found to possess antimicrobial, anticancer, antimalarial, antioxidant, anti-inflammatory, and neuroprotective properties . Chalcone derivatives have shown potential as therapeutic agents for the treatment of a variety of disorders, including cancer . They can be synthesized easily and have been explored for their use in the development of new anti-infective agents . Chalcones also exhibit antibacterial activity against Staphylococcus aureus, a microorganism with increasing resistance to conventional drugs . The diverse biological activities and ease of synthesis make chalcones and their derivatives promising candidates for the design of novel molecules with enhanced medicinal properties . Further research is needed to fully explore the therapeutic potential of chalcones and their derivatives in various applications .
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| The paper does not explicitly mention the significant applications of chalcones. | |
| The significant applications of chalcones include antibacterial, antifungal, anti-inflammatory, and anticancer properties. | |
| The significant applications of chalcones include their use as intermediates in the biosynthesis of flavonoids and as precursors for the synthesis of therapeutic compounds with a wide range of biological activities. | |
| The significant applications of chalcones include antimicrobial, anticancer, antimalarial, antioxidant, anti-inflammatory, antitubercular, antidiabetic, antileishmanial, anti-vitiligo, and neuroprotective properties. | |
| The paper mentions that chalcones have significant applications in medicinal research and development, but does not provide specific details about these applications. |
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What are chalcogen bonds?4 answersChalcogen bonds (ChBs) are noncovalent interactions between electrophilic chalcogen atoms (S, Se, Te) and nucleophilic regions, akin to hydrogen and halogen bonds in strength and directionality. These bonds play crucial roles in various applications, such as solid-state architectures, anion recognition, and organic synthesis. ChBs exhibit different geometries, with Type II structures being stable and engaging in stronger interactions as the chalcogen atom size increases (S < Se < Te). The electrophilicity of chalcogen atoms, particularly sulfur, is essential in initiating chemical reactions and influencing biopharmacological activities of compounds like benzisothiazolinones. Computational studies have highlighted the debate on the relative contributions of covalency, electrostatics, and dispersion in ChB interactions.
How have chalcones been utilized in the development of new drugs and therapies over the past 5 years?5 answersChalcones have been extensively utilized in the past 5 years for developing new drugs and therapies due to their versatile nature. These α,β-unsaturated ketones have been incorporated into various heterocyclic structures, enhancing their pharmacological potential. Chalcones have been synthesized using diverse methods like condensation, Claisen-Schmidt condensation, and rearrangement reactions, leading to the creation of novel chalcone derivatives with reactive functional groups. The resulting chalcone derivatives have shown promising biological activities such as antimicrobial, anticancer, antioxidant, and anti-inflammatory properties, making them valuable candidates for drug development. Additionally, chalcone-based Schiff bases have been highlighted for their significant role in treating various ailments and their applications in drug design and synthesis.
What is chalcone?5 answersChalcone is a group of naturally occurring compounds that have various biological effects, including anti-inflammatory, anti-cancer, and antibacterial properties. It is a fascinating and well-studied group of organic molecules that has immense therapeutic and excellent photophysical properties. Chalcones are 1,3-diaryl-2-propen-1-ones, which are the precursors for flavonoids and isoflavonoids. They are considered as one of the most useful, readily available intermediates in heterocyclic synthesis and can be utilized to make a variety of heterocyclic compounds. Chalcones and their derivatives exhibit promising biological activities against cancer hallmarks and have the potential to be used as anticancer agents. Chalcones are also of high medicinal significance due to their α,β-unsaturated ketone functionality, and numerous functional modifications have been reported. Chalcone scaffold has great potential for use in the design and development of inhibitors for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
How can chalcone be synthesized?5 answersChalcone can be synthesized through various methods. One method involves the Claisen-Schmidt condensation of 3,4-dimethoxybenzaldehyde and 2,4-dihydroxyacetophenone using KOH 40% as a catalyst. Another method is the green synthesis approach using grinding technique, which is eco-friendly and solvent-free. Additionally, chalcones can be synthesized using recyclable ionic liquids as catalysts under ultrasonification, resulting in high yields and environmentally friendly reactions. Microwave synthesis has also been used to synthesize chalcone compounds, providing better cytotoxic activity. The condensation of 2-acetyl pyridine with different aromatic aldehydes in 40% alkali is another method for chalcone synthesis. These methods offer different advantages such as mild reaction conditions, high yields, and environmentally benign procedures.
What are the therapeutic applications of naringenin chalcone?5 answersNaringenin chalcone has therapeutic applications in various areas. It has been found to have antioxidant, antitumor, antiviral, antibacterial, anti-inflammatory, antiadipogenic, and cardioprotective effects. In adipocytes, naringenin chalcone promotes the production of adiponectin, a hormone involved in metabolic processes, and enhances mitochondrial energy metabolism, leading to insulin-sensitizing effects. Additionally, naringenin chalcone has been shown to inhibit angiogenesis, making it a potential treatment for diseases involving abnormal blood vessel formation. Furthermore, naringenin chalcone derivatives have been investigated for their potential in treating viral disorders, including viral lesions caused by Herpes Simplex virus. Overall, naringenin chalcone and its derivatives show promise in various therapeutic applications, including antioxidant, metabolic, antiangiogenic, and antiviral treatments.
What are the different types of chalcone epoxides?5 answersChalcone epoxides are a type of compound that can be synthesized through various reactions. One method involves treating chalcone-epoxide 1 with lithium tetramethylpiperidide, resulting in the formation of two anions: enolate 3 and the remote anion 4. An addition reaction then occurs between anion 4 and the unreacted starting material 1, leading to the formation of diastereoisomeric products 5 and 6. Another approach involves the Claisen-Schmidt condensation reaction between selected aldehydes and ketones. This reaction yields a variety of chalcones, such as thiophen-2-aldehydeacetophenone (TAAP), furan-2-aldehydeacetophenone (FAAP), 2-hydroxynapthaldehyde acetophenone (HNAP), and cinnamaldehydeacetophenone (CAAP). These chalcones can then be further transformed into quinoxalines through treatment with bromine water, acetic acid, and tetramethylenediamine. Additionally, prenylated chalcones, such as 2,4-dihydroxy-3-C-prenylacetophenone and 2,4-dihydroxy-5-C-prenylacetophenone, can be synthesized by treating resacetophenone with 2-methylbut-3-en-2-ol in the presence of BF3.Et2O as the catalyst.