scispace - formally typeset
Search or ask a question

What are the challenges associated with the use of solvents in making solutions for electrospinning? 


Best insight from top research papers

The challenges associated with the use of solvents in making solutions for electrospinning include the detrimental effect on the structural integrity of collagen fibers, even when using non-fluorinated solvents such as acid-based solvents . Another challenge is the low precursor utilization ratio in conventional solution electrospinning, which is usually less than 20 wt% . Additionally, the selection of solvents is crucial as the evaporation rate needs to be controlled for successful electrospinning. Some solvents may have evaporation rates that are either too low or too high, making electrospinning impossible at ambient conditions . Hydrophilic polymers pose challenges in the solvent electrospinning process, which need to be addressed . Finally, the complete removal of non-volatile solvents and the exploration of a coagulation collection process for fiber recovery are challenges that need to be overcome .

Answers from top 5 papers

More filters
Papers (5)Insight
The challenges associated with the use of solvents in making solutions for electrospinning include the difficulty of keeping the cellulose solution stable during the electrospinning process and the need for complete removal of non-volatile solvents.
The challenges associated with the use of solvents in making solutions for electrospinning are addressed in the paper.
The challenges associated with the use of solvents in electrospinning include low precursor utilization ratio and the difficulty of solvent recovery for large-scale production of ultrafine fibers.
The paper does not explicitly mention the challenges associated with the use of solvents in making solutions for electrospinning.
The paper does not specifically address the challenges associated with the use of solvents in making solutions for electrospinning.

Related Questions

What are the common challenges faced during clinical trials of electrospun vascular grafts?5 answersDuring clinical trials of electrospun vascular grafts, common challenges include compliance mismatch, thrombus development, intimal hyperplasia, and low hemocompatibility. These issues hinder successful grafting and can lead to complications such as suture site rupture and endothelial damage. Additionally, synthetic vascular grafts like Dacron® and Teflon® often face limitations in terms of hydrophobic surfaces, which are hostile to cell growth, impacting their translation to clinical trials for small diameters. To address these challenges, researchers have been developing tissue-engineered grafts with suitable materials and optimized fabrication techniques to improve control over graft characteristics and functionality. The integration of advanced fabrication technologies like electrospinning, molding, and 3D printing, along with surface modification methods, shows promise in enhancing the performance of small-diameter vascular grafts in clinical applications.
How does the selection of solvents impact the process of electrospinning and the resulting fibers' performance in various applications?4 answersThe selection of solvents in the electrospinning process has a significant impact on the resulting fibers' performance in various applications. Low volatile solvents, such as N, N-dimethylformamide (DMF), can slow down solvent volatilization and reduce the diameter of electrospun fibers, leading to increased crystallinity and improved water absorption. The solvent composition, including the mixture of ethanol (EtOH) and DMF, affects the structural properties of electrospun fibers, such as fiber diameter distribution, viscoelastic properties, and degree of crystallinity. Solvents like dimethyl sulfoxide (DMSO) can produce electrospun membranes with good morphology and high crystallinity, making them suitable for piezoelectric applications. The properties of solvents, such as boiling temperature and dielectric constant, also influence the diameter and uniformity of electrospun fibers, with low boiling temperature solvents delivering smaller diameter fibers. Additionally, the selection of solvents can optimize the performance of electrospun membranes in terms of solvent resistance, thermal stability, and separation efficiency.
What is the recent trend in electrospinning?5 answersRecent trends in electrospinning include the utilization of supramolecular systems as electrospinning compounds, the incorporation of graphene as a nanofiller in electrospun nanofibers, and the development of nonconventional electrospinning methods for industrial-scale manufacturing. Supramolecular systems, such as phospholipids, surfactants, crown ether derivatives, and cyclodextrins, have been used to generate tailor-made nanofibers. Graphene-based electrospun nanofibers have shown promise in various fields including biomedical, chemical, defense, and environmental applications. Nonconventional electrospinning methods, such as needleless and syringeless electrospinning, have been explored to improve productivity and enable the production of nanofibers that are difficult to spin using traditional techniques. These recent trends in electrospinning demonstrate advancements in material selection, structure design, and performance research for physical sensors, as well as the potential for large-scale adoption of electrospun physical sensors.
Is electrospinning cellulose acetate with glycerol possible?5 answersElectrospinning cellulose acetate with glycerol is possible and has been studied in the context of producing nanofibers for various applications. Glycerol has been used as a co-solvent in cellulose acetate solutions to enhance the long-term thermal stability and recyclability of the electrospinning process. The addition of small molar quantities of glycerol has been shown to suppress the accumulation of undesirable side reactions and improve the stability of the cellulose acetate solution. Additionally, the incorporation of glycerol into the solvent mixture does not exacerbate the rate of cellulose depolymerization and maintains high solubility of cellulose. These findings suggest that electrospinning cellulose acetate with glycerol can be a viable approach for producing nanofibers with improved properties for various applications.
What are the limitations of electrospun scaffolds?5 answersElectrospun scaffolds have certain limitations. One limitation is the inconsistent picture of fibroblast behavior due to the highly variable features of different 3D culture systems. Another limitation is the lack of scalability and applicability of current platforms used for electrical stimulation in vitro, which require large external equipment and wires and electrodes immersed in the culture media. Additionally, electrospun nanofibers often have a closely packed 2D membrane structure, which limits cellular infiltration, nutrition diffusion, and thickness. The lack of a thorough understanding of cell behavior with respect to the availability and spatial distribution of bioactive molecules in 3D fibrous scaffolds is another limitation. Finally, electrospun poly-caprolactone fibers have a limited range of applications in tissue regeneration due to their lack of specific biological role in supporting tissue regeneration.
What are the main limitations of electrospinning technology for dermal replacement?5 answersElectrospinning technology for dermal replacement has several limitations. Conventional strategies, such as random, aligned, and core-shell technologies, have poor mimicking of the native tissue and do not resemble the mechanical and structural properties of the skin. Additionally, commercially available bioengineered skin substitutes created using electrospinning have a high incidence of infection, lack mechanical integrity, and have a slow rate of tissue ingrowth from the surrounding wound margin. Furthermore, there is a need for more sophisticated fabrication strategies to generate biomimetic and complex constructs that closely resemble the native skin. The optimization of physicochemical-structural properties of electrospun scaffolds and their in vivo biological performance in animal models is also an area that requires further improvement. Overall, the limitations of electrospinning technology for dermal replacement highlight the need for advanced strategies, such as hybrid structures and cell and in situ electrospinning, to overcome these challenges.