Katja Schenke-Layland

TL;DR: In this paper, a review summarizes the advances in in vivo and in vitro applications of tissue-engineered skin and highlights novel efforts in the design of complex disease-in-a-dish models for studies ranging from disease etiology to drug development.

TL;DR: The combination of natural proteins and synthetic polymers to create electrospun fibrous structures resulted in scaffolds with favorable mechanical and biological properties, including higher tensile strength when compared to collagen/elastin/PCL constructs.

TL;DR: This review provides a summary of current approaches that employ ECM and ECM-like materials, orECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine and discusses the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy.

TL;DR: The enzymatic decellularization process of heart valves revealed a time-dependent loss of cells, ECM components and biomechanical strength, suggesting ECM-integrity may be compromised with prolonged incubation.

TL;DR: Optimized organoid culture methods are described that efficiently and reliably produce cortical and basal ganglia structures similar to those in the human fetal brain in vivo and are demonstrated for modeling the teratogenic effects of Zika virus on the developing brain and identifying more susceptibility receptors and therapeutic compounds that can mitigate its destructive actions.