What are the clinical data regarding palmoplantar pustulosis?
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Clinical data on palmoplantar pustulosis (PPP) indicate its association with conditions like relapsing polychondritis . Treatment options for PPP include topical corticosteroids as first-line therapy, oral acitretin for systemic treatment, and phototherapy like UVA1, NB-UVB, and 308-nm excimer laser . Apremilast has shown efficacy in Japanese patients with PPP, leading to significant improvements in disease severity and patient-reported symptoms, with sustained benefits through week 32 . Metal allergy, tonsillitis, and smoking are suggested etiological factors for PPP, with metal allergens potentially triggering the condition, although the exact mechanism remains unclear . Overall, while various treatments exist for PPP, including targeted therapies like secukinumab, ustekinumab, and apremilast, further research is needed to address evidence gaps and optimize management strategies based on different disease phases and comorbidities .
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| Clinical data suggest metal allergy, specifically to titanium, may contribute to palmoplantar pustulosis, as seen in a case where pustular eruptions recurred at the site of therapeutic titanium insertion. | |
| Apremilast showed significant efficacy in treating Japanese patients with Palmoplantar Pustulosis, improving disease severity and symptoms with sustained benefits through week 32, with manageable adverse events. | |
| Clinical data show palmoplantar pustulosis is a rare manifestation in relapsing polychondritis, distinct from other conditions with saddle nose deformity, such as granulomatosis with polyangiitis and sarcoidosis. | |
| Clinical data on palmoplantar pustulosis include topical corticosteroids as first-line, oral acitretin for systemic treatment, and phototherapy options like UVA1 and NB-UVB, with ongoing research on targeted therapies. | |
| Clinical data on palmoplantar pustulosis include topical corticosteroids as first-line, oral acitretin for non-joint cases, immunosuppressants for arthritis, phototherapy options, and investigations on targeted therapies' efficacy. |
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