Damien Sène

TL;DR: The trial showed that low-dose interleukin-2 was not associated with adverse effects and led to Treg recovery and concomitant clinical improvement in patients with HCV-induced vasculitis, an autoimmune condition.

TL;DR: In this paper, the authors found that auto-antibodies neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections.

TL;DR: It is indicated that rituximab combined with Peg-IFN-alpha/ribavirin is well tolerated and more effective than Peg-ifN- alpha/ ribavirin in HCV-MC.

TL;DR: It is reported that PD-1 is upregulated on Natural Killer cells from patients with Kaposi sarcoma, and the existence of this negative checkpoint fine-tuning NK activation highlights the possibility that manipulation of thePD-1 pathway may be a strategy for circumventing tumor escape not only from the T cell-, but also the NK-cell mediated immune surveillance.

TL;DR: Hydxychloroquine had no efficacy in patients with anti-SSA autoantibodies, high IgG levels, or systemic involvement, and among patients with primary Sjögren syndrome, the use of hydroxy chloroquine compared with placebo did not improve symptoms during 24 weeks of treatment.