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What are the current methods for surface modification of paper-based analytical devices? 


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Surface modification of paper-based analytical devices can be achieved through various methods. One method involves the use of a UV curing varnish layer, which can significantly improve surface flatness and water resistance of paper substrates . Another method utilizes stencil printing with sticky notes and a thermal transfer ink ribbon, along with office appliances . Additionally, direct printing of electrochemical sensors on a biodegradable paper substrate can be achieved using commercial gold and silver inks, with different substrate treatment strategies such as hydrophobic gas-phase coating, selective hydrophobic silane ink printing, and selective hydrophobic coating printing . Another approach involves the modification of paper cellulose with water-insoluble oxidants for distance readout of reducing substances on microfluidic paper-based analytical devices . Finally, the application of Raman enhancement layers to paper substrates enables surface-enhanced Raman scattering (SERS) platforms, which offer low-cost, versatility, and high sensitivity for analyte detection .

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Surface modification methods for paper-based analytical devices include applying Raman enhancement layers to enable Surface-Enhanced Raman Scattering (SERS), enhancing sensitivity, enabling single-molecule detection, and offering cost-effective, versatile, and recyclable platforms.
Four methods include direct printing on bare paper, hydrophobic gas-phase coating, selective hydrophobic silane ink printing, and blocking paper porosity with SU-8 for inkjet-printed electrochemical sensors.
Surface modification of paper substrates for electronic devices includes UV curing varnish layer printing for improved flatness and water resistance, and transparent PEDOT:PSS electrode transfer for perovskite light-emitting devices.
The current method for surface modification of paper-based analytical devices involves a stencil printing technique using sticky notes, thermal ink ribbons, and office appliances, as proposed in the study.

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