What are the effects of isoorientin on the markers of Alzheimer's disease in APP/PS1 mice?
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Isoorientin, a compound found in certain plants, has been studied for its effects on Alzheimer's disease (AD) markers in APP/PS1 mice. Isoorientin treatment was found to decrease amyloid beta deposition in the brain, specifically in the cortex and hippocampus, which are regions affected by AD . Additionally, isoorientin reduced tau hyperphosphorylation, a characteristic feature of AD, and attenuated neuroinflammation in the brains of APP/PS1 mice . The treatment also improved spatial learning and memory in these mice . These findings suggest that isoorientin has potential as a therapeutic agent for AD by targeting multiple pathogenic hallmarks of the disease, including amyloid beta deposition, tau hyperphosphorylation, and neuroinflammation .
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22 Citations | Isoorientin administration in APP/PS1 mice attenuated GSK-3β overactivation, tau hyperphosphorylation, Aβ deposition, and neuroinflammation, while improving synaptic long-term potentiation and spatial memory. |
6 Citations | The effects of isoorientin on markers of Alzheimer's disease in APP/PS1 mice include a significant decrease in amyloid beta 42-positive deposition in the cortex and hippocampus. |
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