How age at pregnancy associated with preeclampsia?5 answersAdvanced maternal age has been linked to an increased risk of developing preeclampsia during pregnancy. Research has shown that older pregnant individuals are more likely to experience preeclampsia. Additionally, the risk of preeclampsia is further influenced by factors such as pre-pregnancy body mass index (BMI), with overweight or obese individuals having a higher risk. Furthermore, the study by Sun et al. suggests that pre-pregnancy BMI mediates the association between advanced maternal age and the risk of preeclampsia, highlighting the importance of considering both factors in assessing the risk of developing this condition during pregnancy. Overall, maternal age, in conjunction with pre-pregnancy BMI, plays a significant role in the likelihood of experiencing preeclampsia during pregnancy.
What are the most effective diagnostic methods for preeclampsia?5 answersThe most effective diagnostic methods for preeclampsia include the use of angiogenic biomarkers such as soluble fms-like tyrosine kinase-1 and placental growth factor, as well as the analysis of the amino acid profile of blood plasma. These methods have been shown to accurately diagnose and predict the severity of preeclampsia-associated outcomes. Additionally, spontaneous and resonant Raman spectroscopy of blood plasma has been found to be effective in providing an express diagnosis of preeclampsia. Another diagnostic method involves determining the mean arterial pressure (MAP) and the mean dry thrombocyte level in pregnant women, and calculating a diagnostic index (Y) based on these values. These diagnostic methods offer higher accuracy, sensitivity, and specificity in diagnosing preeclampsia.
Which models and guidelines are most effective in detecting high-risk pregnancies?5 answersVarious models and guidelines have been found effective in detecting high-risk pregnancies. The Health Belief Model, Bandura's self-efficacy theory, the World Food Program flip-chart, the Dietary Guidelines for Americans, and the Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women are some of the models and guidelines that have shown positive effects in educating pregnant women about high-risk pregnancy detection. Additionally, chromosomal microarray analysis (CMA) has been identified as an effective tool for prenatal diagnosis of high-risk pregnancies with fetal structural anomalies found in ultrasonography or positive findings. Furthermore, the use of multi-class classification with the LSTM method and the Random Forest method with feature optimization have shown promise in classifying the risk of pregnant women and predicting pregnancy risk levels respectively. These models and guidelines, along with advanced diagnostic techniques, can contribute to the early detection and management of high-risk pregnancies.
What are the predictive models in healthcare?5 answersPredictive models in healthcare are utilized to forecast risk variables and improve treatment procedures for better patient outcomes. These models include linear regression, logistic regression, decision trees, and artificial neural networks. They are used for two main applications: predicting the likely course of a medical condition (prognosis) and predicting the consequences of a particular treatment decision. The goal is to move beyond population averages and provide personalized predictions. Feature selection and model validation are crucial steps in building predictive healthcare models. Machine learning methods, such as deep learning, have shown promising results in healthcare, particularly in identifying patterns in observational data and predicting outcomes. Predictive models have the power to prescribe optimal clinical therapy and personalize treatment for individual patients. Clinical prediction models are statistical tools that estimate the probability of specific outcomes based on patient or disease-specific input variables.
What are the different types of preeclampsia?4 answersPreeclampsia is a pregnancy-related multisystem disorder that can be classified into different types. One classification is based on the timing of onset, distinguishing between early-onset or placental preeclampsia and late-onset or maternal preeclampsia. Another classification is based on the severity, with placental preeclampsia being more severe than maternal preeclampsia. Additionally, there is evidence suggesting that preeclampsia may have subtypes with different pathophysiologies, leading to variations in clinical outcomes, prognosis, organ systems involved, and risk factors. These subtypes can be identified through clustering methods that group preeclampsia cases based on their specific pathophysiologies. Overall, preeclampsia is a complex condition with different types and subtypes, each with its own characteristics and implications for management and treatment.
Is there any research into prediction models and gestational hypertension?2 answersResearch has been conducted on prediction models for gestational hypertension. One study used machine learning methods to establish a prediction model based on real pregnancy examination data. They found that with data from all gestational weeks, the predictive AUC for hypertension was 0.87. Another study focused on metabolomics as a technology to improve prediction of hypertension in pregnancy. They conducted a systematic literature search and will present the current use and performance of metabolomics for predicting gestational hypertension. A review assessed the methodological quality of prediction models for gestational hypertension and preeclampsia. They found that most studies did not completely follow guidelines in prediction model development and reporting, and recommended adherence to these guidelines for improved application of prediction models in clinical practice. Additionally, a retrospective case-control study found that first trimester maternal mean arterial pressure, placental growth factor, and pregnancy-associated plasma protein A can predict hypertensive disorders of pregnancy. Finally, a radiomics nomogram based on diffusion-weighted imaging and apparent diffusion coefficient maps was developed to predict pre-eclampsia from gestational hypertension.