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What are the psychiatric effects of Lactobacillus Bacterium in humans? 

Meta-analysis
Lactobacillus helveticus
Lactobacillus rhamnosus
Depression (economics)
GABAergic
Best insight from top research papers

The psychiatric effects of Lactobacillus bacterium in humans have been the subject of extensive research, revealing a complex interaction between gut microbiota and mental health. Studies have shown that various strains of Lactobacillus can have beneficial effects on psychiatric disorders, including depression and anxiety, by influencing the microbiota-gut-brain axis. For instance, Lactobacillus mucosae has demonstrated the ability to alleviate neuropsychiatric disorders by attenuating altered microbiota and reducing inflammation in the gastrointestinal tract, which is linked to cognitive decline and depression in mice . Similarly, Lactobacillus casei strain Shirota (LcS) intake was associated with alleviated depressive symptoms in patients with major depressive disorder (MDD) or bipolar disorder (BD), suggesting a beneficial effect partly through its association with the abundance of Actinobacteria in the gut microbiota . Moreover, Lactobacillus species have been documented to prevent depression- and anxiety-like behavior by maintaining homeostatic levels of IFNγ, which mediates behavioral and circuit-level responses to environmental stressors . This protective role of Lactobacillus against acute psychosocial stress has been further supported by findings that suggest certain strains can reduce or prevent deleterious effects of stress, such as elevated levels of soluble fractalkine . Additionally, Lactobacillus helveticus strains have been highlighted for their health-promoting qualities, including potential benefits in addressing persistent stress-induced depression . The anti-depressive and GABAergic effects of Lactobacillus rhamnosus strains also underscore the therapeutic potential of probiotics in mood regulation and depression treatment . However, it's important to note that while some studies find a negative correlation between Lactobacillus counts and psychiatric symptoms, such as sleep disturbances, the overall role of these bacteria in the pathophysiology of bipolar disorder and their impact on stress response (e.g., serum cortisol levels) remains to be fully elucidated . Collectively, these findings suggest that Lactobacillus bacterium can have significant psychiatric effects in humans, offering promising avenues for the treatment of psychiatric disorders through modulation of the gut microbiota. However, further research is needed to fully understand the mechanisms involved and to optimize probiotic treatments for psychiatric conditions .

Answers from top 9 papers

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Papers (9)Insight
Open access•Journal Article•DOI
Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity
Fernanda-Marie Tette, Samuel Kwofie, Michael T. Wilson 
22 Mar 2022-Current Issues in Molecular Biology
10 Citations
Lactobacillus rhamnosus strains produce microbial GABA, restoring GABAergic signaling to alleviate depression and counteract addiction-induced HPA axis hyperactivity, showcasing therapeutic potential for psychiatric effects in humans.
Journal Article•DOI
Effect of Probiotic Lactobacillus helveticus in Various Health Disorder
Pooja Verma
23 Jun 2022-Current traditional medicine
1 Citations
Lactobacillus helveticus, a probiotic bacterium, may help alleviate stress-induced depression by influencing the gut-brain axis, potentially improving psychiatric well-being in humans.
Open access•Journal Article•DOI
Bifidobacterium and Lactobacillus Counts in the Gut Microbiota of Patients With Bipolar Disorder and Healthy Controls.
Emiko Aizawa, Hirokazu Tsuji, Takashi Asahara, Takuya Takahashi, Toshiya Teraishi, Sumiko Yoshida, Norie Koga, Kotaro Hattori, Miho Ota, Hiroshi Kunugi 
18 Jan 2019-Frontiers in Psychiatry
60 Citations
Increasing Lactobacillus counts in the gut may benefit sleep disturbances in bipolar disorder, as shown by a negative correlation between Lactobacillus counts and sleep on the HAM-D scale.
Journal Article•DOI
The effects of probiotics on mood and emotion.
Lindsey Kane, Julie Kinzel 
01 May 2018-JAAPA : official journal of the American Academy of Physician Assistants
18 Citations
Lactobacillus and Bifidobacterium probiotics show anxiolytic effects on the central nervous system in humans, suggesting potential psychiatric benefits, including mood and emotion regulation.
Open access•Journal Article•DOI
Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota
Machiko Otaka, Hiroko Kikuchi-Hayakawa, Jun Ogura, Hiroshi Ishikawa, Yukihito Yomogida, Miho Ota, Shinsuke Hidese, Ikki Ishida, Masanori Aida, Kazunori Matsuda, Mitsuhisa Kawai, Sumiko Yoshida, Hiroshi Kunugi 
10 May 2021
19 Citations
The probiotic Lacticaseibacillus paracasei strain Shirota (formerly Lactobacillus casei strain Shirota) can alleviate depressive symptoms in patients, potentially linked to Actinobacteria abundance in the gut microbiota.
Patent
Lactobacillus compositions and uses thereof
Magnus Hillman, Siv Ahrné, Gunilla Önning 
05 Jun 2020
The psychiatric effects of Lactobacillus in humans include reducing and preventing deleterious effects of acute psychosocial stress, such as elevated soluble fractalkine levels.
Open access•Journal Article•DOI
Effect of Probiotics on Psychiatric Symptoms and Central Nervous System Functions in Human Health and Disease: A Systematic Review and Meta-Analysis
Charlotte Le Morvan de Sequeira, Charlotte Hengstberger, Paul Enck, Isabelle Mack 
30 Jan 2022-Nutrients
23 Citations
Lactobacillus Bacterium showed slight improvements in depression and psychiatric distress in humans. However, its overall impact on psychiatric symptoms remains inconclusive based on the meta-analysis.
Open access•Posted Content•DOI
Lactobacillus maintains IFNγ homeostasis to promote behavioral stress resilience
Andrea R. Merchak, Samuel A. Wachamo, Lucille C. Brown, Alisha Thakur, Ryan M. Brown, Courtney Rivet-Noor, Tula Raghavan, Alban Gaultier 
11 May 2023-bioRxiv
Lactobacillus maintains IFNγ levels, promoting stress resilience in mice. It may offer potential as a probiotic therapy for mood disorders in humans.
Book Chapter•DOI
Potential beneficial effects of Bifidobacterium breve A1 on cognitive impairment and psychiatric disorders
Ryo Okubo, Jin-zhong Xiao, Yutaka Matsuoka 
01 Jan 2021
Not addressed in the paper.

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What are the effects of Bifidobacterium strains on the human gut microbiota?5 answersBifidobacterium strains have various effects on the human gut microbiota. Bifidobacterium breve M-16V and B. longum BB536, when encapsulated in acid-resistant microcapsules, increased the amount of bifidobacteria in the stool compared to the powder formulation. The distribution of glycoside hydrolase genes in B. bifidum varies with age, affecting the phenotypic results. Probiotic supplementation with Bifidobacterium bifidum (Bf-688) improved clinical symptoms and altered gut microbiota composition in patients with attention-deficit/hyperactivity disorder (ADHD). Bifidobacterium longum subsp. longum BCBL-583 administration changed the composition of gut microbiota and reduced cholesterol levels in a high-fat diet mouse model. B. pseudolongum UMB-MBP-01 and B. pseudolongum ATCC25526 have distinct genetic repertoires, immune modulation capabilities, and effects on gut microbiota composition.
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