What are the short-term and long-term health effects of silicon toxicity in humans?
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Short-term and long-term health effects of silicon toxicity in humans vary based on exposure scenarios and particle sizes. Studies show that exposure to silica nanoparticles can lead to adverse effects on various body systems. Acute exposure to silica nanoparticles can result in cell membrane damage, reduced cell viability, and mitochondrial dysfunction in corneal epithelial cells. Repeated exposure of macrophages to silica nanomaterials can induce alterations in macrophage responses, affecting phagocytosis, NO production, and cytokine release. Furthermore, the toxic effects of silica nanoparticles are influenced by their physiochemical properties, exposure routes, and toxicokinetics. Both amorphous and crystalline silica nanoparticles have been associated with pulmonary toxicity, triggering oxidative stress and potentially leading to respiratory diseases.
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| Papers (5) | Insight |
|---|---|
| Short-term effects of silica toxicity include cytotoxicity and fibrosis, while long-term effects involve silicosis, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease. | |
18 Citations | Short-term and long-term health effects of silica nanoparticle toxicity in humans include cardiovascular, dermal, respiratory, neural, hepatic, genetic, immune, reproductive, and renal system complications. |
| Short-term effects of silica nanoparticles include ROS generation and inflammation, while long-term inhalation of low concentrations shows low systemic toxicity in humans. | |
20 Citations | Short-term effects of silicon dioxide nanoparticles on the cornea include cell damage and reduced viability. Long-term effects were not addressed in the paper. |
| The study focuses on the bioaccumulation and functional changes in macrophages due to silica nanoparticles, highlighting potential short-term and long-term toxicity risks associated with human exposure. |
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What are the roles of silicon in plants?3 answersStep 1:
Silicon plays a crucial role in plant growth and stress tolerance. It provides structural and mechanical strength to plants by interacting with cell wall components, enhancing stress resistance, and increasing rigidity and stability. Additionally, silicon accumulation in plants can alleviate metal(loid) toxicity and contribute to phytoremediation of contaminated soils. Furthermore, silicon can confer greater resistance to biotic and abiotic stresses, such as water stress, salinity, and toxicity of heavy metals, while also enhancing plant production ^[Pooja Singh]^[Fatin Munir]^[Daniel Puppe].
Step 2:
[Pooja Singh] - "Context_1"
[Fatin Munir] - "Context_2"
[Daniel Puppe] - "Context_3"- "Context_4"- "Context_5"
Step 3:
Silicon plays a crucial role in plant growth and stress tolerance. It provides structural and mechanical strength to plants by interacting with cell wall components, enhancing stress resistance, and increasing rigidity and stability ^[Pooja Singh]. Additionally, silicon accumulation in plants can alleviate metal(loid) toxicity and contribute to phytoremediation of contaminated soils ^[Fatin Munir]^[Daniel Puppe]. Furthermore, silicon can confer greater resistance to biotic and abiotic stresses, such as water stress, salinity, and toxicity of heavy metals, while also enhancing plant production.