What are the specific transcriptional factors that bind to the promoter region of the PKD1 gene?
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The specific transcription factors that bind to the promoter region of the PKD1 gene are Sp1, Sp3, NF-κB-p65, Tra2-β, RXR, and E2F . These factors play a crucial role in regulating the expression of PKD1. Sp1, Sp3, and NF-κB-p65 transactivate the PKD1 promoter, while Tra2-β binds to a conserved binding site in PKD1 intron 30, affecting PKD1 splicing . RXR and Sp1 are present at the PKD1 proximal promoter and are involved in retinoic acid-induced PKD1 gene regulation . E2F is a potential key regulator of cell cycle-dependent expression of the PKD1 gene . These findings highlight the importance of these transcription factors in the regulation of PKD1 expression.
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34 Citations | The specific transcription factors that bind to the promoter region of the PKD1 gene are AP2, E2F, E-Box, EGRF, ETS, MINI, MZF1, SP1, and ZBP-89. |
| The specific transcription factors that bind to the promoter region of the PKD1 gene are not mentioned in the provided paper. The paper is about the regulation of the KCTD10 gene, not the PKD1 gene. | |
16 Citations | The specific transcription factor that binds to the promoter region of the PKD1 gene is Sp1, as mentioned in the paper. |
1 Citations | The specific transcriptional factors that bind to the promoter region of the PKD1 gene are not mentioned in the provided paper. |
| The specific transcription factors that bind to the promoter region of the PKD1 gene are Sp1, Sp3, and NF-κB-p65. |
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