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Aidong Zhou
Researcher at University of Texas MD Anderson Cancer Center
Publications - 26
Citations - 2174
Aidong Zhou is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Carcinogenesis & Transcription factor. The author has an hindex of 17, co-authored 23 publications receiving 1593 citations. Previous affiliations of Aidong Zhou include Sun Yat-sen University & Hunan Normal University.
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Journal ArticleDOI
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.
Sicong Zhang,Boxuan Simen Zhao,Aidong Zhou,Kangyu Lin,Shaoping Zheng,Zhike Lu,Zhike Lu,Yaohui Chen,Erik P. Sulman,Keping Xie,Oliver Bogler,Sadhan Majumder,Chuan He,Suyun Huang +13 more
TL;DR: This work uncovers a critical function for ALKBH5 and provides insight into critical roles of m6A methylation in glioblastoma and a long non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes the interaction of AL KBH5 withFOXM1 nascent transcripts.
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β-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathway.
TL;DR: A novel β-catenin/LEF1–miR-372&373–DKK1 regulatory feedback loop is demonstrated, which may have a critical role in regulating the activity of Wnt/β- catenin signaling in human cancer cells.
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Tumour suppressor TRIM33 targets nuclear β-catenin degradation
Jianfei Xue,Yaohui Chen,Yamei Wu,Zhongyong Wang,Aidong Zhou,Sicong Zhang,Kangyu Lin,Kenneth Aldape,Sadhan Majumder,Zhimin Lu,Suyun Huang +10 more
TL;DR: It is demonstrated that tripartite motif-containing protein 33 (TRIM33), acting as an E3 ubiquitin ligase, reduces the abundance of nuclear β-catenin protein.
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Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22
Aidong Zhou,Kangyu Lin,Sicong Zhang,Sicong Zhang,Yaohui Chen,Nu Zhang,Jianfei Xue,Zhongyong Wang,Kenneth Aldape,Keping Xie,James R. Woodgett,Suyun Huang +11 more
TL;DR: It is demonstrated that nuclear GSK3β- and USP22-mediated KDM1A stabilization is essential for glioblastoma tumorigenesis.
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FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA-Repair Gene Rad51
Nu Zhang,Xinjian Wu,Lixuan Yang,Feizhe Xiao,Heng Zhang,Aidong Zhou,Zhengsong Huang,Suyun Huang +7 more
TL;DR: Targeting the FoxM1-Rad51 axis may be an effective method to reverse TMZ resistance in recurrent GBM.