What are the factors responsible for attentands to spread infections?5 answersFactors responsible for the spread of infections include population mobility dynamics, community structure, clustering, variations in infectiousness or susceptibility, and variations in closeness of contacts. Recurrent mobility of population among different communities in a network can affect the spreading process of diseases. Small-scale community structures, high mobility ratios, and a large number of temporal communities can help prevent infectious diseases. Clustering is the dominant factor controlling the growth rate of epidemics, while heterogeneity in infectiousness and susceptibility are dominant factors controlling the probability and size of an epidemic. Edge weights, measuring closeness or duration of contacts, have an impact only if correlations exist between different edges. These factors can reinforce each other and have implications for the design of interventions.
How does antibiotic resistance spread?4 answersAntibiotic resistance spreads through horizontal gene transfer (HGT) between bacterial species, particularly through plasmids. Conjugation, a major HGT pathway, is responsible for the dissemination of antibiotic resistance genes (ARGs). Mobile genetic elements (MGEs), such as plasmids and phage-plasmids, play a crucial role in the spread of antibiotic resistance. Plasmids are key drivers of resistance gene transfer, while phage-plasmids carry a diverse range of clinically relevant resistance genes and can infect bacteria distant from the original host. The spread of antibiotic resistance is facilitated by factors such as the production of reactive oxygen species, the SOS response, increased cell membrane permeability, and upregulation of conjugation relevant genes. The timing of antibiotic administration also affects the spread of resistance, with intermediate administration times resulting in maximum plasmid transfer and transconjugant proliferation. The spread of antibiotic resistance is a global concern that requires continuous monitoring and innovative strategies to curtail its dissemination.
How transmission of infectious diseases?3 answersThe transmission of infectious diseases is influenced by various factors such as host characteristics, pathogen properties, and environmental conditions. Super-spreading events, which are extreme forms of transmission heterogeneities, play a significant role in disease dynamics and outbreak spread. Bacterial-viral interactions within a host can lead to heightened dispersal of bacteria and increased shedding of viruses, contributing to transmission heterogeneities. In healthcare settings, the spread of infectious diseases can occur through contact, airborne, or blood-borne means. Hand hygiene is crucial in reducing the spread of pathogens, and proper cleaning and disinfection of reusable equipment are essential. Habitat hotspots can also impact disease transmission in wildlife populations, even when transmission does not occur at the hotspot itself. Understanding the physicochemical properties of respiratory particles is important for preventing the airborne transmission of infectious diseases. Vocalization activities, such as speaking and singing, can contribute to the spread of respiratory pathogens.
Transmission and risk factors of STI's ?3 answersTransmission and risk factors of STIs are influenced by various factors. Non-monogamy is a significant risk factor for acquiring and transmitting STIs, with mutual non-monogamy being a population-level determinant of increased STI spread. In midlife individuals experiencing relationship transitions, STI risk perceptions and practices are shaped by factors at multiple levels, including individual, partnership, peers and communities, and societal factors. In Ghana, symptoms such as painful urination, urethral discharge, multiple sexual partners, and alcohol use are associated with higher rates of gonorrhea in men, while condom use frequency is associated with gonorrhea in women. The adult film industry's STI risk environment is influenced by policy, economic, and social factors, with mandatory testing and exclusion from work based on positive tests being perceived as effective, but condom use being rare. Among indigenous people in the Peruvian Amazon, structural factors such as population mobility, mixing, and environments of risk contribute to vulnerability to HIV transmission.
What are the bacterial etiology of STI's ?3 answersThe bacterial etiology of sexually transmitted infections (STIs) includes Neisseria gonorrhoeae, Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis. These pathogens have been identified in various studies conducted in different countries, including Ghana, Zimbabwe, and South Africa. In these studies, N. gonorrhoeae was found to be the most commonly associated pathogen with urethral discharge in men, while C. trachomatis and M. genitalium were also frequently detected. Additionally, T. vaginalis was identified as a common pathogen in women with vaginal discharge. It is important to note that these studies highlight the need for ongoing monitoring of these pathogens, as well as the importance of syndromic management guidelines and regular empirical testing for both symptomatic and asymptomatic patients.
Does globalization increase the spread of disease?1 answers