What does retain proteins in biomaterials?
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Proteins are retained in biomaterials through processes like protein adsorption, where proteins adhere to the material's surface forming a monolayer that influences cellular response . Factors like hydrophobic and hydration forces, electrostatic interactions, and protein affinity for the surface play crucial roles in protein adsorption . Encapsulation methods, such as the alcohol-free sol-gel process, help retain protein conformation and bioactivity within biomaterials like porous silica matrices . Surface-modified silica gel matrixes offer control over protein-solid interactions, ensuring proteins maintain their native structure and bioactivity, making them suitable for applications like drug delivery systems and immunodiagnostic tools . Overall, the interaction between proteins and biomaterial surfaces is a dynamic process influenced by various chemical and physical properties, ultimately determining the retention of proteins in biomaterials.
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| Papers (5) | Insight |
|---|---|
| Proteins are retained in biomaterials through protein adsorption, influenced by diffusion and affinity, forming a dynamic protein layer before cell interaction. | |
Patent 13 Sep 2000 72 Citations | The process retains proteins in biomaterials by encapsulating them in porous silica matrices via an aqueous colloidal sol-gel method, preserving their conformation and activity even after long-term storage. |
| Proteins are retained in biomaterials through rapid adsorption to the surface, forming a monolayer that influences cellular response by mediating interactions with cells. | |
100 Citations | Porous silica gel matrixes with chemically engineered surfaces retain proteins in biomaterials by controlling protein-solid interactions, ensuring native conformation and bioactivity for applications like drug delivery and immunoassays. |
587 Citations | Proteins are retained in biomaterials due to water-mediated hydrophobic and hydration forces, along with electrostatic interactions, as highlighted in the paper on protein interactions with polymer coatings and biomaterials. |
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