What genes can be removed from Staphylococcus lugdynensis without affecting organism function?
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Deletion of the LytSR genes in Staphylococcus lugdunensis does not impact susceptibility to autolysis or antibiotic-induced death but results in reduced biofilm formation and virulence towards Caenorhabditis elegans, indicating a non-essential role . Additionally, the fbl gene can be removed without affecting fibrinogen binding, as shown by constructing fbl knockout mutants in S. lugdunensis . Furthermore, the lugEF and lugGH transporter genes, along with the LugI protein, play roles in lugdunin secretion and self-resistance, but their deletion does not affect susceptibility to other antimicrobials, suggesting a specific function in lugdunin release and resistance . These findings collectively suggest that LytSR, fbl, lugEF, lugGH, and LugI genes can potentially be removed from S. lugdunensis without compromising essential organism functions.
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| Papers (5) | Insight |
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| Deletion of lugEF transporter genes in Staphylococcus lugdunensis abrogates lugdunin secretion without affecting organism function, while lugGH genes play a dominant role in resistance. | |
1 Citations | Not addressed in the paper. |
| Not addressed in the paper. | |
9 Citations | Deletion of LytSR in Staphylococcus lugdunensis does not affect Triton X-100 induced autolysis or antibiotic susceptibility, suggesting these genes can be removed without impacting organism function. |
15 Citations | The fbl gene can be removed from Staphylococcus lugdunensis without affecting organism function, as it exclusively mediates fibrinogen binding in the strains studied. |
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