Bernhard Krismer

TL;DR: It is shown that nasal Staphylococcus lugdunensis strains produce lugdunin, a novel thiazolidine-containing cyclic peptide antibiotic that prohibits colonization by S. aureus, and a rare example of a non-ribosomally synthesized bioactive compound from human-associated bacteria.

TL;DR: It is shown that targeting of the amidase repeats is based on an exclusion strategy mediated by wall teichoic acid (WTA), and by preventing binding of Atl, WTA directs Atl to the cross‐wall to perform the last step of cell division, namely separation of the daughter cells.

TL;DR: Interestingly, commensal bacteria are able to amplify the innate immune response of human keratinocytes to pathogens by increased induction of AMP expression and abrogation of NF-κB suppression, suggesting that the two activation pathways can act in a synergistic way.

TL;DR: In this article, the stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria, and a direct link between stringent response and the CodY regulon was proposed.

TL;DR: Recent insights into mechanisms that are used by S. aureus to prevail in the human nose and the counter-strategies that are using by other nasal bacteria to interfere with its colonization are discussed.