A
Andreas Peschel
Researcher at University of Tübingen
Publications - 228
Citations - 21972
Andreas Peschel is an academic researcher from University of Tübingen. The author has contributed to research in topics: Staphylococcus aureus & Teichoic acid. The author has an hindex of 74, co-authored 213 publications receiving 19083 citations. Previous affiliations of Andreas Peschel include Brigham and Women's Hospital & Utrecht University.
Papers
More filters
Journal ArticleDOI
Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides.
TL;DR: A role of thed-alanine-esterified teichoic acids which occur in many pathogenic bacteria in the protection against human and animal defense systems is proposed.
Journal ArticleDOI
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
Rong Wang,Kevin R. Braughton,Dorothee Kretschmer,Thanh-Huy L. Bach,Shu Y. Queck,Min Li,Adam D. Kennedy,David W. Dorward,Seymour J. Klebanoff,Andreas Peschel,Frank R. DeLeo,Michael Otto +11 more
TL;DR: A previously uncharacterized set of S. aureus virulence factors are revealed that account at least in part for the enhanced virulence of CA-MRSA.
Journal ArticleDOI
The co-evolution of host cationic antimicrobial peptides and microbial resistance
Andreas Peschel,Hans-Georg Sahl +1 more
TL;DR: It is proposed that CAMPs and CAMP-resistance mechanisms have co-evolved, leading to a transient host–pathogen balance that has shaped the existing CAMP repertoire.
Journal ArticleDOI
Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with L-lysine
Andreas Peschel,Andreas Peschel,Ralph W. Jack,Michael Otto,L. Vincent Collins,Petra Staubitz,Graeme J. Nicholson,Hubert Kalbacher,Willem F. Nieuwenhuizen,Günther Jung,Andrej Tarkowski,Kok P. M. van Kessel,Jos A. G. van Strijp +12 more
TL;DR: A novel staphylococcal gene, mprF, which determines resistance to several host defense peptides such as defensins and protegrins constitutes a novel virulence factor, which may be of general relevance for bacterial pathogens and represents a new target for attacking multidrug resistant bacteria.
Journal ArticleDOI
Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions
TL;DR: Identifying and harnessing highly conserved or species-specific structural features of CWGs offers excellent opportunities for developing new antibiotics, vaccines and diagnostics for use in the fight against severe infectious diseases, such as sepsis, pneumonia, anthrax and tuberculosis.