What ıs comt enzyme?
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Catechol-O-Methyl Transferase (COMT) is an enzyme involved in the inactivation of catecholamine neurotransmitters like dopamine, epinephrine, and norepinephrine . It plays a crucial role in estrogen metabolism and has been identified as a potential immunogenic membrane antigen in pancreatic cancer . COMT enzyme catalyzes the metabolism of dopamine and other catechols in the brain, with investigations into its genetic polymorphisms like Val158Met showing no association with alcohol dependence . In the realm of computational enzyme design, a general approach has been developed to design enzymes with novel functions, focusing on transition state stabilization and active site interactions . Additionally, COMT inhibitors like tolcapone and entacapone are utilized in Parkinson's disease treatment to prevent the peripheral degradation of levodopa, enhancing its efficacy in the brain .
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20 Jun 2019 | COMT enzyme is involved in catecholamine neurotransmitter inactivation. The rs4680 polymorphism in the COMT gene affects enzyme activity, with AA genotype linked to predisposition to volleyball in athletes. |
| Computational enzyme design is a method to create efficient protein catalysts for various reactions by utilizing computational approaches to design enzymes with novel functions. | |
| COMT (catechol-o-methyl-transferase) is an enzyme inhibited by tolcapone and entacapone in Parkinson's disease treatment, allowing increased levodopa levels to cross the blood-brain barrier for improved efficacy. | |
| Catechol-O-methyl transferase (COMT) is an enzyme that metabolizes dopamine and other catechols in the brain, with the Val158Met polymorphism studied for its association with alcohol dependence. |
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