O
Oksana Suchowersky
Researcher at University of Alberta
Publications - 176
Citations - 9980
Oksana Suchowersky is an academic researcher from University of Alberta. The author has contributed to research in topics: Parkinson's disease & Population. The author has an hindex of 57, co-authored 166 publications receiving 9219 citations. Previous affiliations of Oksana Suchowersky include Alberta Children's Hospital & University of Calgary.
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Journal ArticleDOI
Pramipexole vs levodopa as initial treatment for Parkinson disease: a 4-year randomized controlled trial.
Robert G. Holloway,Ira Shoulson,Stanley Fahn,Karl Kieburtz,Anthony E. Lang,Kenneth Marek,Michael P. McDermott,John Seibyl,William J. Weiner,Bruno Musch,Cornelia Kamp,Mickie Welsh,Aileen Shinaman,Rajesh Pahwa,Lynn Barclay,Jean P. Hubble,Peter A. LeWitt,Janis M. Miyasaki,Oksana Suchowersky,Mark Stacy,David S. Russell,Blair Ford,John P. Hammerstad,David E. Riley,David G. Standaert,Frederick Wooten,Stewart A. Factor,Joseph Jankovic,Farah Atassi,Roger Kurlan,Michel Panisset,Ali H. Rajput,Robert L. Rodnitzky,Cliff Shults,Giselle Petsinger,Cheryl Waters,Ronald F. Pfeiffer,Kevin M. Biglan,Leona Borchert,Amy Montgomery,Laura Sutherland,Carolyn Weeks,Maryan DeAngelis,Elspeth Sime,Susan Wood,Carol Pantella,Mary Harrigan,Barbara Fussell,Sandra Dillon,Barbara Alexander-Brown,Pamela Rainey,Marsha Tennis,Elke Rost-Ruffner,Diane Brown,Sharon Evans,Debra Berry,Jean Hall,Theresa Shirley,Judith Dobson,Deborah Fontaine,Brenda Pfeiffer,Alicia Brocht,Susan E. Bennett,Susan Daigneault,Karen Hodgeman,Carolynn O'Connell,Tori Ross,Karen Richard,Arthur Watts +68 more
TL;DR: Initial treatment with pramipexole resulted in lower incidences of freezing, somnolence, and edema and provided for better symptomatic control, as measured by the Unified Parkinson's Disease Rating Scale, compared with initial treatment with levodopa, which resulted in similar quality of life.
Journal ArticleDOI
Practice parameter: Initiation of treatment for Parkinson’s disease: An evidence-based review: Report of the Quality Standards Subcommittee of the American Academy of Neurology
TL;DR: The authors conclude that selegiline has very mild symptomatic benefit with no evidence for neuroprotective benefit and levodopa provides superior motor benefit but is associated with a higher risk of dyskinesia.
Journal ArticleDOI
Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care.
Sara L. Sawyer,Taila Hartley,David A. Dyment,Chandree L. Beaulieu,Jeremy Schwartzentruber,Amanda C. Smith,H M Bedford,Geneviève Bernard,Francois P. Bernier,Bernard Brais,Dennis E. Bulman,J. Warman Chardon,David Chitayat,Johnny Deladoëy,Bridget A. Fernandez,Patrick Frosk,Michael T. Geraghty,Brenda Gerull,William T. Gibson,Robert M. Gow,Gail E. Graham,Jane Green,Elise Héon,Gabriella Horvath,A.M. Innes,Nada Jabado,Raymond H. Kim,Robert K. Koenekoop,Aneal Khan,Ordan J. Lehmann,Roberto Mendoza-Londono,Jacques L. Michaud,Sarah M. Nikkel,L S Penney,Constantin Polychronakos,Julie Richer,Guy A. Rouleau,Mark E. Samuels,Victoria Mok Siu,Oksana Suchowersky,Mark A. Tarnopolsky,Grace Yoon,Farah R. Zahir,Jacek Majewski,Kym M. Boycott +44 more
TL;DR: The analysis of this dataset showed that these known disease genes were not identified prior to WES enrollment for two key reasons: genetic heterogeneity associated with a clinical diagnosis and atypical presentation of known, clinically recognized diseases.
Journal ArticleDOI
CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
J-M Lee,Eliana Marisa Ramos,Junghee Lee,Tammy Gillis,Jayalakshmi S. Mysore,Michael R. Hayden,Simon C. Warby,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Ferdinando Squitieri,S. Orobello,S. Di Donato,Estrella Gómez-Tortosa,Carmen Ayuso,Oksana Suchowersky,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,Randi Jones,Tetsuo Ashizawa,Samuel Frank,Marie Saint-Hilaire,Steven M. Hersch,H. D. Rosas,Diane Lucente,Madeline Harrison,Andrea Zanko,Ruth K. Abramson,Karen Marder,Jorge Sequeiros,J.S. Paulsen,Georg Bernhard Landwehrmeyer,Richard H. Myers,Marcy E. MacDonald,James F. Gusella +37 more
TL;DR: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat, and the rate of HD pathogenesis leading to motor diagnosis is determined by a completely dominant action of the longest expanded allele and as yet unidentified genetic or environmental factors.
Journal ArticleDOI
Practice Parameter: Diagnosis and prognosis of new onset Parkinson disease (an evidence-based review) Report of the Quality Standards Subcommittee of the American Academy of Neurology
Oksana Suchowersky,Stephen G. Reich,J. Perlmutter,Theresa A. Zesiewicz,Gary S. Gronseth,William J. Weiner +5 more
TL;DR: Predictive factors for more rapid motor progression, nursing home placement, and shorter survival time include older age at onset of PD, associated comorbidities, presentation with rigidity and bradykinesia, and decreased dopamine responsiveness.