What is importance of loquat in anti viral?4 answersLoquat has been found to possess antiviral activity. It has been shown to have inhibiting effects on the influenza A virus. Additionally, luteolin, a bioactive component found in loquat leaves, has been found to have antiviral activity against pseudorabies virus (PRV). Luteolin was able to inhibit PRV replication, decrease viral mRNA and protein expression, reduce apoptosis of infected cells, and improve survival rates in mice. These findings suggest that loquat and its bioactive components have potential as antiviral agents against various viruses.
How can the anticancer effects of plants be used to treat cancer?4 answersPlant-derived compounds have shown potential in treating cancer by targeting multiple cancer hallmarks and inhibiting tumor growth. These compounds, such as vincristine, taxol, and resveratrol, have been used in clinical settings for cancer treatment. Medicinal plants contain bioactive compounds that have therapeutic properties and can be used as an alternative to synthetic medicine. Studies have shown that plant extracts and their active principles, such as those from Alpina galaga, Urtica dioica, and Nigella sativa, have exhibited anticancer activities by reducing cell proliferation, inducing programmed cell death, and triggering cell-cycle arrest. Natural remedies, including herbs like acacia, basil, and garlic, have also been found to have promising anticancer effects. The use of plant-derived natural products provides a diverse range of chemical structures and low toxicity, making them a potential source for the development of new and more effective anticancer therapies.
What is the role of plant-derived compounds in anticancer drug discovery?5 answersPlant-derived compounds play a significant role in anticancer drug discovery. These compounds, such as flavonoids, polyphenols, and bioactive phytocompounds, have demonstrated antioxidant, anti-inflammatory, and anticancer properties. They can scavenge free radicals, prevent inflammation, and inhibit the formation of tumors. Plant-derived compounds have been used in combination therapies with other anticancer agents, leading to effective management of various malignancies. Additionally, the incorporation of plant-derived compounds into nanoparticles or antibodies can improve their bioavailability and enhance their therapeutic effects. These compounds have also been shown to modulate various signaling pathways involved in cancer development and progression, such as P13K/AKT, NF-κB, JNK, and ERK. Overall, plant-derived compounds offer potential advantages in terms of selectivity, efficacy, and reduced off-target toxicities, making them valuable in the discovery and development of anticancer drugs.
Why the plant mediated protease inhibitors are have importance in cancer therapy?5 answersPlant-mediated protease inhibitors have importance in cancer therapy due to their ability to inhibit proteases that are involved in cancer progression. Proteases play a central role in several signaling pathways related to cancer, and their dysregulation is associated with tumor metastasis. Plant protease inhibitors have been found to be effective against various human cancers, including breast, lung, colon, and prostate cancer. They have been shown to inhibit the growth and proliferation of cancer cells, induce apoptosis, and suppress tumor angiogenesis. Bowman-Birk inhibitors, in particular, have been extensively studied for their potential in cancer prevention. Additionally, plant protease inhibitors have shown promise in the treatment of other diseases such as cardiovascular diseases, osteoporosis, inflammatory diseases, and neurological disorders. Their diverse mechanisms of action and specificity make them attractive candidates for targeted cancer therapies.
What are the Natural product anti cancer drug?5 answersNatural products have been widely used as a source of therapeutic ingredients for the development of anti-cancer drugs. Several plant-based drugs, such as vincristine, etoposide, topotecan, and paclitaxel, have shown promising anti-tumor activity and are currently used in clinical practice. Additionally, natural products with immunomodulatory properties, such as curcumin, resveratrol, zerumbone, quercetin, genistein, and betulinic acid, are being explored as adjuvant therapies in cancer treatment. Natural products and their derivatives have demonstrated potential anti-cancer properties, including cytotoxicity, proliferation inhibition, apoptosis induction, metastasis retardation, angiogenesis suppression, and improved chemotherapy. Plant-derived anti-cancer agents in late preclinical development or early clinical trials include taxol, vincristine, vinblastine, topotecan, irinotecan, etoposide, paclitaxel, and docetaxel. Furthermore, the conjugation of natural products with other bioactive molecules has led to the development of novel, bifunctional drugs for cancer therapy, such as ADCs, PDCs, ApDCs, PROTACs, and AUTOTACs.
Which Philippine herbal plants have anti-cancer properties?4 answersPhilippine medicinal plants with potential anti-cancer properties include Allium spp. bulbs (bawang), Andrographis paniculata leaves (sinta), Cocos nucifera oil (niyog), Euphorbia hirta leaves (tawa-tawa), Euphorbia neriifolia leaves (sorosoro), Moringa oleifera leaves (malunggay), Ocimum basilicum leaves (balanoy), Piper nigrum seeds (paminta), Vitex negundo leaves (lagundi), and Zingiber officinale rhizome (luya). These plants contain phytochemicals that have been studied for their anti-cancer effects. For example, Peganum harmala, a medicinal herb, contains β-carboline alkaloids, particularly harmine, which demonstrate notable anticancer properties by targeting apoptosis, autophagy, abnormal cell proliferation, angiogenesis, metastasis, and cytotoxicity. Theaflavins, phenolic components present in black tea, have also shown anti-cancer potential by inhibiting proliferation, survival, and migration of cancer cells and promoting apoptosis. Annona squamosa leaves contain flavonoids such as quercetin and rutin, which have been shown to have anticancer properties. These Philippine herbal plants offer potential avenues for the development of novel anti-cancer therapies.