What is isomeric substitution?
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Isomeric substitution involves replacing one atom or group in a molecule with another having similar electronic and steric properties. This concept plays a crucial role in drug design, aiming to enhance drug efficacy or alter pharmacological profiles. Isosteric replacements, such as oxygen by NH or CH2 equivalents, are common examples of this strategy. In a different context, isosteric substitutions of the peptide CO group by CS and CSe affected conformational preferences and prolyl cis–trans isomerization, showcasing the impact of such substitutions on molecular behavior. Furthermore, in the realm of coordination chemistry, isomeric substitution reactions can lead to different geometrical dispositions in metal complexes, influencing their reactivity and stability. Overall, isomeric substitution is a versatile tool in various fields, influencing molecular structure, properties, and reactivity.
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32 Citations | Isomeric substitution is a strategy discussed in the paper to control emission behavior of luminogens by replacing isomers, switching between aggregation-induced phosphorescence and dual-state emission. |
5 Citations | Isomeric substitution refers to the process of interchanging isomeric forms of a compound, as seen in the isomerization of [Co(hexacyclen)]3+ from mer to fac in the presence of specific anions. |
| Isosteric substitution involves replacing atoms or groups in a molecule with similar electronic and steric properties. Examples include replacing oxygen with NH or CH2 equivalents. | |
12 Citations | Isomeric substitution refers to the process where different isomeric forms of a complex undergo ligand exchange, leading to changes in the spatial arrangement of ligands around the central metal atom. |
1 Citations | Isosteric substitution involves replacing a peptide CO group with CS or CSe, affecting conformational preferences and prolyl cis–trans isomerization in proline-containing peptides, as studied in the research. |
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