What is Lig E?
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Lig E is a type of DNA ligase that differs from the general paradigm by not requiring complete encirclement of the DNA substrate for engagement. It has been shown that Lig E proteins do not need additional domains or loops for substrate binding, as confirmed by the structure of a Lig E-type DNA ligase bound to the nicked DNA-adenylate reaction intermediate. On the other hand, Lig v 1, a major allergen from privet pollen grains, forms a homodimer and belongs to the Ole e 1 protein family, which promotes specific IgE production leading to allergies through cross-reactivity with other pollen sources. Lig v 1's structure reveals a β-barrel fold stabilized by conserved disulphide bonds, with unique loop structures and a C-terminal α-helix.
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4 Citations | Lig v 1 is a major allergen from the Oleaceae family, specifically from privet pollen grains, known to induce specific IgE production and potentially influence the development of allergies. |
| Lig E refers to the fused-ring bulky 1,1,3,3,5,5,7,7-octaethyl-s-hydrindacen-4-yl group used in (E)-1,2-diaryldigermenes synthesis, influencing their structural characteristics and absorption properties. | |
31 Citations | Lig E is a newly identified subunit of RNA polymerase found in Gram-positive bacteria, resembling phage proteins like Gp2, possibly involved in protection from phage infection. |
Open access 01 Jan 1986 | L.E.G.O. is an interactive graphics system for creating, viewing, and manipulating geometric figures and objects, serving as an electronic tool for geometric constructions in teaching geometry and computer graphics. |
9 Citations | Lig E is a minimal scaffold DNA ligase that binds DNA without additional domains or loops, demonstrating robust substrate engagement and essential attributes of DNA ligation. |
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