What is m6a?
Best insight from top research papers
N6-methyladenosine (m6A) is the most common reversible methylation modification of eukaryotic mRNA. It plays a significant role in tumorigenesis and affects various aspects of RNA metabolism, including splicing, stability, translocation, and translation. m6A is involved in the development and progression of cancer, and aberrant m6A modifications are associated with cancer occurrence, development, progression, and prognosis. The m6A machinery consists of "writers" that install m6A marks, "erasers" that demethylate m6A, and "readers" that determine the fate of m6A-modified targets. m6A readers have been recognized as regulators of RNA metabolism and participants in various biological processes. The m6A modification of RNA is dynamic and reversible, and it plays a critical role in the occurrence and progression of tumors by regulating RNA metabolism. m6A modification has been shown to be involved in the development of various cancers and has potential for tumor treatment.
Answers from top 4 papers
More filters
| Papers (4) | Insight |
|---|---|
| m6A is a posttranscriptional RNA modification that involves the methylation of adenosine at the N6 nitrogen atom. It is the most abundant cellular modification in mammalian mRNA. | |
| m6A is the most abundant covalent modification of RNA, induced by various cellular stresses including viral infection. It is a reversible and dynamic process that plays a role in gene regulation and viral replication. | |
| m6A is the most common reversible methylation modification of eukaryotic mRNA and plays a significant role in tumorigenesis. (Answer from the paper) | |
| m6A is a common internal RNA modification that occurs on mRNAs or ncRNAs and affects various aspects of RNA metabolism. |
Related Questions
What is the role of m6A for metabolism in macrophage?4 answersN6-methyladenosine (m6A) plays a pivotal role in the regulation of macrophage metabolism, impacting various aspects of macrophage function and contributing to the pathogenesis of metabolic diseases. m6A modification is one of the most prevalent internal transcriptional modifications, influencing RNA metabolism, including processing, stability, translation, and degradation, which in turn affects macrophage development, activation, and polarization, as well as pyroptosis in metabolic disorders. The dynamic and reversible nature of m6A modification, regulated by methyltransferases, demethylases, and m6A-binding proteins, is essential for mRNA metabolism and various biological activities, including those relevant to macrophage function.
In the context of metabolic diseases, m6A-mediated macrophage function has been shown to affect diseases such as atherosclerosis and nonalcoholic fatty liver disease (NAFLD). Specifically, m6A methylation contributes to endothelial cell injury, macrophage response, inflammation, and smooth muscle cell response in atherosclerosis, highlighting its significant role in the pathogenesis of atherosclerotic diseases. Furthermore, the m6A modification pattern and related signatures in microglia, which are the central nervous system's equivalent of macrophages, under pro-inflammatory and anti-inflammatory conditions, suggest that m6A serves as a novel and useful regulator during the inflammatory response, which is closely related to metabolic processes.
Moreover, m6A modification has been implicated in the regulation of autophagy, a process important for maintaining cellular function and metabolism, which can indirectly influence macrophage metabolism and function. The involvement of m6A in inflammation, a response to infection and injury in various diseases, further underscores its essential role in macrophage-mediated metabolic processes. Collectively, these findings highlight the multifaceted role of m6A in regulating macrophage metabolism and its potential as a target for clinical diagnosis and treatment in metabolic and inflammatory diseases.
What is the role of m6A for macrophage?4 answersN6-methyladenosine (m6A) plays a pivotal role in macrophage function, influencing various aspects of their behavior and response in the immune system. m6A modification is closely related to macrophage phenotype and dysfunction, affecting their development, activation, and polarization, as well as their involvement in pyroptosis and metabolic disorders. This modification is essential for the regulation of RNA metabolism, which in turn impacts macrophage responses in diseases such as rheumatoid arthritis (RA) and atherosclerosis.
In RA, m6A methylation modifications, including circular RNA and microRNA interactions, are involved in the inflammatory response, affecting macrophage polarization towards a pro-inflammatory state, which contributes to joint and cartilage destruction. Similarly, in the context of monocyte-to-macrophage differentiation and polarization, m6A and other RNA modifications like 5hmC have been identified as regulators of gene expression programs essential for macrophage function in innate immunity.
Moreover, m6A modification has been implicated in the regulation of tumor-associated macrophages (TAMs) in cervical cancer, influencing their infiltration, polarization, and the survival outcomes of patients. In the broader context of hematopoiesis, m6A mRNA modification plays a critical role in the maintenance of hematopoietic stem and progenitor cells, which are precursors to macrophages.
Research has also highlighted the importance of m6A regulators in the diagnosis and treatment of abdominal aortic aneurysm (AAA), suggesting their roles in macrophage-mediated inflammation. In atherosclerosis, m6A modification mediates inflammatory responses in macrophages, influencing the progression of the disease. The stiffness of the tissue environment has been found to modulate macrophage inflammatory responses through m6A-associated molecular mechanisms, affecting macrophage activation and stiffness sensing. Lastly, m6A methylation contributes to macrophage responses in atherosclerosis and atherosclerotic diseases, affecting lipid metabolism, inflammation, and smooth muscle cell response.
In summary, m6A modification significantly influences macrophage function across various physiological and pathological contexts, impacting their development, polarization, and response to inflammation and disease.
What are the cellular roles of m6A?5 answersThe N6-methyladenosine (m6A) modification of RNA plays crucial roles in various cellular processes. It is involved in hematopoietic cell development, maintenance of hematopoietic stem and progenitor cells, and progression of malignant hematopoiesis. Additionally, m6A modification affects RNA metabolism, including mRNA stability, decay, splicing, and lncRNA processing, contributing to tumor development and progression. Furthermore, m6A modification influences B-cell maturation, immune response, and immune regulation by affecting RNA splicing, translation, and stability. Overall, m6A plays a critical role in regulating RNA stability, metabolism, and various cellular functions, making it a key player in normal development and disease progression.
Does M6A play a role in cancer?5 answersM6A plays a crucial role in cancer development and progression through various mechanisms, including impacting RNA metabolism, metabolic reprogramming, programmed cell death, tumor metastasis, and therapy resistance. Aberrant m6A modification is a hallmark of cancer and has been shown to regulate the proliferation and invasion of cancer cells. Additionally, m6A modification has been implicated in the development of various cancers, including colorectal cancer (CRC). Targeting m6A modification or its regulatory proteins has emerged as a potential approach for cancer therapy. Furthermore, m6A modification can affect tumor progression, metabolism, ferroptosis, and the tumor immune microenvironment, thereby influencing tumor immunotherapy. Overall, the evidence suggests that m6A plays a significant role in cancer and has therapeutic implications.
WHAT is m6A modification?4 answersN6-methyladenosine (m6A) modification is a dynamic and reversible posttranscriptional RNA modification that occurs on mRNAs or ncRNAs. It is mediated by m6A regulators, including "writers" that install m6A marks, "erasers" that demethylate m6A, and "readers" that determine the fate of m6A-modified targets. m6A modification affects various aspects of RNA metabolism, such as splicing, stability, translocation, and translation. Aberrant m6A modification is associated with cancer occurrence, development, progression, and prognosis. It plays a crucial role in tumorigenesis and tumor progression. m6A modification impacts multiple RNA metabolic processes and plays a vital role in numerous biological processes. In hematopoiesis, m6A modification is involved in the generation and maintenance of hematopoietic cells during embryogenesis and the functional maintenance of hematopoietic stem and progenitor cells in adulthood. Overall, m6A modification is a prevalent RNA modification that has important roles in RNA metabolism and various biological processes, including cancer and hematopoiesis.
What is m6a?5 answersN6-methyladenosine (m6A) is the most common reversible methylation modification of eukaryotic mRNA. It plays a significant role in tumorigenesis and is involved in various aspects of RNA metabolism, including splicing, stability, translocation, and translation. m6A is also abundant in non-coding RNAs (ncRNAs) and regulates their production, stability, and degradation. The modification of m6A in ncRNAs and the expression of m6A-related proteins are closely related to the tumor microenvironment (TME), which consists of tumor stromal cells, immune cells, and factors associated with tumor occurrence and development. The crosstalk between m6A modification-associated ncRNAs and TME affects tumor proliferation, angiogenesis, invasion and metastasis, and immune escape. Additionally, m6A modification is found in RNA viruses and DNA viruses, where it can either positively or negatively affect viral replication. The effects of m6A on target RNAs depend on the recognition and binding of m6A reader proteins, which play roles in RNA metabolism, gene expression, and viral replication.