What is the current understanding of the molecular mechanisms involved in the synthesis of acyclovir drug?
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The synthesis of acyclovir (ACV) involves various molecular mechanisms. ACV can be prepared using synthetic materials like 5-aminoimidazole-4-carboxamide, guanine, and other purine derivatives, as discussed in . Additionally, the hybrid drug [Pt(en)(acv)2]2+ was synthesized by reacting acyclovir with a platinum complex, showcasing a bifunctional complex with specific conformational equilibriums . Efficient synthesis of acyclovir β,γ-methylene/dihalomethylenetriphosphates was achieved through redox condensation, highlighting high reactivity towards bisphosphonates . Furthermore, monomeric and polymeric complexes of ACV with metals like Ni, Co, Zn, and Cd have been characterized, revealing unique structural features and interactions with ACV ligands . These studies collectively contribute to understanding the molecular mechanisms involved in the synthesis and complexation of the antiviral drug acyclovir.
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2 Citations | The synthesis of acyclovir involves 1,3-dipolar cycloaddition to insert 1,2,3-triazol-(4 and 5)-ylmethyl spacers between heterocyclic bases and the alkylating chain, as described in the study. |
| The synthesis of metal-acyclovir complexes reveals structural characteristics and unprecedented recognition of free acyclovir molecules by Ni(or Co)-ACV, providing insights into molecular interactions in drug synthesis. | |
| The synthesis of Acyclovir β,γ-methylene/dihalomethylene triphosphates involves redox condensation with 2,2′-dipyridyldisulfide/PPh3 system and high reactivity towards bisphosphonates promoted by 4,5-dicyanoimidazole (DCI). | |
35 Citations | The synthesis involves preparing a platinum(II)-acyclovir complex with two acyclovir molecules coordinated to the platinum atom, showing fast conformational equilibrium without a preferred state. |
7 Citations | The synthesis of acyclovir involves 5-aminoimidazole-4-carboxamide, guanine, and purine derivatives. These materials play a crucial role in the preparation process of acyclovir. |
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