scispace - formally typeset
Search or ask a question

What is the effect Epicatechin on myostatin? 

Best insight from top research papers

Epicatechin has been shown to have an inhibitory effect on myostatin expression . Several studies have demonstrated that epicatechin consumption in humans leads to an improvement in the follistatin to myostatin ratio, indicating an increase in follistatin levels and a decrease in myostatin levels . In a study conducted on patients with Becker muscular dystrophy, epicatechin supplementation resulted in a decrease in myostatin levels . Additionally, epicatechin has been found to inhibit myostatin gene expression in skeletal muscle in response to cycling exercise training . These findings suggest that epicatechin has a positive effect on myostatin regulation, leading to an increase in follistatin levels and a decrease in myostatin levels.

Answers from top 4 papers

More filters
Papers (4)Insight
Epicatechin treatment normalized the blood levels of myostatin, a recognized inducer of muscle atrophy, in the ovariectomy-induced loss of skeletal muscle structure-function in female rats.
The effect of Epicatechin on myostatin is not mentioned in the provided paper.
The paper states that the consumption of Epicatechin (EPI) in humans is associated with the inhibition of myostatin (MTSN) and the induction of follistatin (FST), resulting in an improvement in the FST:MSTN ratio.

Related Questions

Do erythrocytes express myostatin?5 answersErythrocytes do express myostatin, as evidenced by studies showing the presence of myostatin and its receptor system in blood cells. Additionally, research indicates that myostatin plays a role in regulating the antioxidant capacity of erythrocytes after exhaustive exercise, with knockdown of myostatin accelerating the pentose phosphate pathway and enhancing erythrocyte antioxidant capacity. This suggests that myostatin has a direct impact on erythrocyte function, particularly in response to oxidative stress induced by strenuous physical activity. Furthermore, targeting myostatin signaling at the mRNA level has been proposed as a novel approach to inhibiting myostatin activity, indicating the significance of myostatin in various physiological processes, including those involving erythrocytes.
How does the body weight of myostatin knockout mice compare to wild-type controls?5 answersMyostatin knockout (Mstn-KO) mice exhibit differences in body weight compared to wild-type controls. Mstn-KO mice generally show larger skeletal muscles and altered organ weights, indicating a significant impact on body composition. In contrast, studies on GH gene manipulation models show that GH receptor knockout (GHR-/-) mice with reduced GH/IGF-1 action have increased muscle strength and reduced body weight, while bovine GH transgenic (bGH) mice with excess GH/IGF-1 action display higher body weight and lean mass. Additionally, pharmacologic blockade of the myostatin pathway results in muscle hypertrophy without significant changes in body weight, highlighting the complex relationship between myostatin and body mass regulation. Therefore, myostatin knockout can lead to variations in body weight compared to wild-type controls, influenced by factors like muscle mass, GH/IGF-1 levels, and metabolic changes.
How does myostatin contribute to the development and progression of diabetic nephropathy in patients?5 answersMyostatin contributes to the development and progression of diabetic nephropathy (DN) by activating the nuclear factor-κB pathway in macrophages. Increased serum levels of mannose-binding lectin (MBL), a crucial mediator in DN, promote inflammatory responses in macrophages, leading to enhanced IL-1β production and M1 polarization. MBL directly induces inflammatory and fibrotic markers in renal cells during co-culture. In db/db mice, downregulation of MBL ameliorates blood glucose, triglyceride, urine protein, glomerular and tubular injuries, as well as renal inflammation and fibrosis. Overexpression of MBL promotes macrophage infiltration in the kidney. These findings suggest that MBL, through its activation of the nuclear factor-κB pathway in macrophages, plays a crucial role in the progression of DN.
What is myostatin?5 answersMyostatin is a protein that belongs to the transforming growth factor β (TGF-β) superfamily. It was initially discovered as a negative regulator of skeletal muscle growth. Myostatin is produced by skeletal myofibers and circulates in the blood, acting back on myofibers to limit muscle growth. It functions as a master regulator of skeletal muscle mass and plays a role in controlling tissue size. Recent studies have also shown that myostatin has potential activities outside of the musculoskeletal system, including in various reproductive organs such as the ovary, placenta, and uterus. In addition, myostatin has been associated with metabolic syndrome, a complex metabolic disorder characterized by obesity, hyperglycemia, hypertension, and hyperlipidemia. Overall, myostatin is a protein that regulates muscle growth and has implications in various physiological and pathological conditions, including reproductive disorders and metabolic syndrome.
What is the effect of epicatechin on weight loss?4 answersEpicatechin has been shown to have beneficial effects on weight loss. In a study by Tufiño et al., epicatechin administration during the first two weeks of gestation resulted in a decrease in systolic blood pressure and weight in a preclampsia model. Another study by de los Santos et al. found that epicatechin administration in male offspring of obese mothers led to a significant decrease in visceral fat and adipocyte size. Additionally, Milenkovic et al. demonstrated that epicatechin supplementation mitigated the adverse effects of a high-fat diet on metabolic markers and cognitive function in mice. These findings suggest that epicatechin may play a role in promoting weight loss and improving metabolic profile.
What are the effects of kimchi phytochemicals on skeletal muscle?5 answersKimchi phytochemicals have been found to have effects on skeletal muscle. Polyphenols, which are natural phytochemicals found in kimchi, have been shown to attenuate muscle atrophy and enhance muscle health by their potent antioxidant and anti-inflammatory properties. Additionally, phytochemicals such as curcumin and sulforaphane have been studied for their impact on muscle function, recovery, and prevention of muscle atrophy. Furthermore, phytochemicals that promote glucose uptake, such as resveratrol, piceatannol, and gingerol, have been shown to activate AMPK and improve glucose intolerance in type 2 diabetes model mice. These findings suggest that kimchi phytochemicals have the potential to benefit skeletal muscle health by preventing muscle atrophy and improving glucose uptake and metabolism.

See what other people are reading

What role does patient satisfaction play in the success of a marketing campaign targeting referral hospitals?
5 answers
Patient satisfaction plays a crucial role in the success of a marketing campaign targeting referral hospitals. Studies have shown that patient satisfaction positively influences hospital brand image perception, enhances hospital loyalty, and impacts patient loyalty and satisfaction. Additionally, patient satisfaction is affected by the 7P's marketing mix, which includes product, price, place, promotion, process, people, and physical building, emphasizing the importance of these factors in ensuring patient satisfaction in hospitals. Therefore, a marketing campaign targeting referral hospitals should focus on enhancing patient satisfaction through effective relationship marketing strategies, optimizing the marketing mix elements, and prioritizing patient experience to build a positive brand image and foster patient loyalty.
Does single number or even number of group members in a team matter?
5 answers
The number of group members in a team significantly impacts team dynamics and performance. Research indicates that smaller groups tend to be more effective in decision-making, while multiple team membership can enhance individual performance benefits in estimation tasks. Group size influences the collective understanding of relationships in tasks, with larger groups generally showing increased accuracy but decreased efficiency beyond a certain threshold. The relationship between team size and team task performance is complex, with varying effects based on task complexity and coordination requirements. In mobile learning applications, teams of two are often more successful than individuals or larger teams, highlighting the importance of team size in enhancing activity levels and team-building.
Can consumption pattern be different by socioeconomic status?
5 answers
Consumption patterns can indeed vary based on socioeconomic status. Research indicates that individuals of higher socioeconomic status tend to have lower odds of consuming sugar-sweetened beverages (SSBs) compared to those of lower status. In a study conducted in Kenya, wealthier households spent more on food purchases, especially at supermarkets, compared to poorer households, impacting their dietary diversity. Additionally, a study in Indonesia found that income and family size influenced the consumption patterns of fishermen households, with a positive impact on their consumption patterns. These findings collectively highlight the influence of socioeconomic status on consumption patterns, emphasizing the need for policies addressing socioeconomic inequalities in food purchasing practices.
How to improve breastfeeding rate in Sub-Saharan Africa?
4 answers
To improve breastfeeding rates in Sub-Saharan Africa, implementing breastfeeding promotion programs is crucial. These programs have been shown to significantly increase exclusive breastfeeding rates at < 1 month after birth. Additionally, focusing on timely initiation of breastfeeding is essential, as it plays a vital role in reducing neonatal and infant mortality. Addressing factors such as cesarean sections, institutional delivery, maternal age, education status, and household characteristics can positively impact early initiation of breastfeeding. Furthermore, promoting gender equality in breastfeeding practices is important, as studies have shown higher odds for early breastfeeding initiation of female children compared to male children in the region. Prioritizing policies, behavioral change communication programs, and supportive care for mothers can help bridge the gaps and enhance breastfeeding rates in Sub-Saharan Africa.
When was the first miRNA study in humans?
5 answers
The first study on miRNAs in humans dates back to the investigation conducted by Zuzanna Nowicka et al., where they explored the potential of serum miRNAs as biodosimeters for radiation exposure. This study involved analyzing miRNA expression in patients undergoing total body irradiation, demonstrating the feasibility of using miRNAs to predict radiation exposure and dose in humans. The research utilized next-generation sequencing to profile miRNA expression, leading to the development of an 8-miRNA-based model with high accuracy in detecting radiation exposure levels. The study's findings highlighted the utility of miRNAs as functional biodosimeters for precise identification of individuals exposed to significant radiation doses, showcasing the early exploration of miRNAs in a human context for radiation exposure assessment.
How long are CSR reports?
5 answers
Clinical Study Reports (CSRs) vary significantly in length, with some being extremely extensive. For instance, CSRs included in a study ranged from 357 pages to a staggering 11,456 pages, showcasing the substantial variability in their size. Another analysis found that the median length of various sections within CSRs ranged from 5 pages for report synopses to 337 pages for attached tables, highlighting the detailed and exhaustive nature of these reports. Additionally, a study focusing on CSRs for randomized controlled trials (RCTs) of erythropoiesis-stimulating agents (ESAs) in cancer patients reported a median CSR length of 1,825 pages, emphasizing the comprehensive data contained within these reports. Overall, CSRs can be incredibly lengthy documents, providing in-depth information on clinical trials.
The influence of Cognitive-behavioral therapy (CBT) on ADHD symptomatology?
5 answers
Cognitive Behavioral Therapy (CBT) has shown efficacy in reducing ADHD symptoms in both children and adults. In school-aged children, CBT is recommended as a non-pharmacological intervention to decrease the severity of ADHD symptoms, particularly in those with moderate symptoms. For adults with ADHD, CBT has been found to effectively reduce core ADHD symptoms, emotional symptoms, depression, anxiety, and improve self-esteem and quality of life. Additionally, a systematic review highlighted the effectiveness of CBT in reducing ADHD symptoms in children and adolescents, emphasizing the importance of exploring CBT alongside pharmacological interventions for better outcomes. However, a study focusing on adolescents found that group CBT without parent involvement did not show incremental treatment effects on ADHD symptoms and impairments, suggesting limitations in this specific CBT approach.
How mouth breathing affect upper airway?
5 answers
Mouth breathing can significantly impact the upper airway by causing or exacerbating conditions such as obstructive sleep apnea (OSA) and adenoid hypertrophy. Mouth breathing syndrome, often triggered by upper airway obstructions, can lead to morphological changes and affect various stomatognathic functions. Studies have shown that mouth breathing during drug-induced sleep endoscopy (DISE) is associated with increased OSA severity and a higher prevalence of upper airway collapse, particularly at the lateral pharyngeal wall and tongue base. Additionally, the interaction between adenoid hypertrophy and mouth breathing can further worsen upper airway obstruction, potentially leading to inflammation and respiratory tract issues. Rapid maxillary expansion (RME) has been explored as a potential treatment to alleviate mouth breathing by increasing nasal cavity volume, although its impact on nasopharyngeal and oropharyngeal volume remains inconclusive.
What are the most effective supplements for inhibiting muscle loss shoulder surgery?
5 answers
Protein supplements have shown effectiveness in preventing muscle loss post-surgery, particularly after bariatric and orthopedic procedures. Studies have highlighted the benefits of protein supplementation in maintaining muscle mass and improving protein levels. Additionally, nutritional supplements like milk, omega-3 fatty acids, and curcumin have been explored for their potential in reducing delayed onset muscle soreness (DOMS) associated with physical activity, although their effectiveness in preventing and treating DOMS remains inconclusive. Therefore, a combination of protein supplements, particularly those rich in leucine, glutamine, arginine, and cysteine, along with other nutrients like N-acetyl-cysteine and Vitamin C, could be beneficial in inhibiting muscle loss and promoting recovery post-shoulder surgery.
How is menopause different in india?
5 answers
Menopause in India differs from Western countries due to the average age of menopause being lower, at around 46.2 years compared to 51 years in the West. Premature menopause is becoming more prevalent in India, with a higher risk of cardiovascular diseases associated with it. Studies have shown that the average age at menopause in India is around 46.6 years, with variations observed throughout the country. Menopause is considered a significant issue in urban middle-aged Indian women due to factors like globalization and urbanization, leading to emerging health problems. Culturally, menopause signifies a transition in women's roles, with Indian women experiencing this change around the age of 45 years, which is earlier than in the Western world.
What infections are connected to rheumatoid arthritis?
4 answers
Various infections are associated with rheumatoid arthritis (RA), posing challenges in diagnosis and treatment. Common infections that mimic RA include viral infections like Parvovirus B19, Hepatitis B, Hepatitis C, Chikungunya, and HIV, mycobacterial infections such as tubercular septic arthritis, bacterial arthritis, brucellosis, and Lyme disease. Patients with RA are susceptible to infections due to immunosuppressive therapies, with gram-negative bacteria being the predominant pathogens, including Pseudomonas aeruginosa and Escherichia coli. The incidence of infections in RA patients using biological or targeted synthetic drugs is increased, with non-serious infections outnumbering serious infections by a factor of 10:1. Understanding the diverse infectious mimics and risk factors for infections in RA is crucial for effective management and improved outcomes.