What is the effect of charge dependence on tissue distribution?
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The effect of charge on tissue distribution is dependent on the charge distribution on the surface of the molecule. In the case of antibodies, a balanced charge distribution was found to be optimal for total tumor exposure, while negatively charged and balanced charged antibodies showed similar results in other tissues . However, antibodies with positive charge patches resulted in increased serum clearance but enhanced tumor and organ uptake, leading to higher tissue-to-serum ratios . This differential effect of charge patches on antibody surfaces was also observed in the interstitial space of muscle and skin, indicating the impact of charge on uptake and availability . Additionally, the charge of ferritin was found to affect its uptake by components of the mononuclear phagocytic system, as well as its distribution in glomeruli . These findings highlight the importance of charge in the biodistribution and tumor uptake of molecules, providing insights for the design of molecules with tailored properties .
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47 Citations | The effect of charge dependence on tissue distribution is observed in the interstitial exclusion of charged macromolecules, which is influenced by fixed negative charges in the extracellular matrix. |
Open access•Journal Article 16 Citations | The effect of charge dependence on tissue distribution is observed in the uptake of ferritin by components of the mononuclear phagocytic system (MPS) and the persistence of ferritin in glomeruli. |
| The effect of charge dependence on tissue distribution is explored in the paper. The study found that antibodies with positive charge patches had increased serum clearance but enhanced tumor and organ uptake, leading to higher tissue-to-serum ratios. | |
| The effect of charge dependence on tissue distribution is explored in the paper. The study found that a balanced charge distribution on antibodies resulted in optimal tumor exposure, while positive charge patches increased tumor and organ uptake. |
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