H
Helge Wiig
Researcher at University of Bergen
Publications - 158
Citations - 7342
Helge Wiig is an academic researcher from University of Bergen. The author has contributed to research in topics: Interstitial fluid & Extracellular fluid. The author has an hindex of 41, co-authored 154 publications receiving 6230 citations. Previous affiliations of Helge Wiig include Vanderbilt University Medical Center & University of California, Davis.
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Journal ArticleDOI
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aleksanteri Aspelund,Salli Antila,Steven T. Proulx,Tine V. Karlsen,Sinem Karaman,Michael Detmar,Helge Wiig,Kari Alitalo +7 more
TL;DR: The presence of a lymphatic vessel network in the dura mater of the mouse brain is discovered and it is shown that these dural lymphatic vessels are important for the clearance of macromolecules from the brain.
Journal ArticleDOI
Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer
Helge Wiig,Melody A. Swartz +1 more
TL;DR: This review integrates the biophysical, biomechanical, and biological aspects of interstitial and lymph fluid and its transport in tissue physiology, pathophysiology, and immune regulation.
Journal ArticleDOI
Immune cells control skin lymphatic electrolyte homeostasis and blood pressure
Helge Wiig,Agnes Schröder,Wolfgang Neuhofer,Jonathan Jantsch,Christoph W. Kopp,Tine V. Karlsen,Michael Boschmann,Jennifer Goss,Maija Bry,Natalia Rakova,Anke Dahlmann,Sven Brenner,Olav Tenstad,Harri Nurmi,Eero Mervaala,Hubertus Wagner,F. X. Beck,Dominik N. Müller,Dontscho Kerjaschki,Friedrich C. Luft,David G. Harrison,Kari Alitalo,Jens Titze +22 more
TL;DR: The results suggest that the skin contains a hypertonic interstitial fluid compartment in which MPS cells exert homeostatic and blood pressure-regulatory control by local organization of interstitial electrolyte clearance via TONEBP and VEGFC/VEGFR3-mediated modification of cutaneous lymphatic capillary function.
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PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis
Marko Uutela,Maria Wirzenius,Karri Paavonen,Iiro Rajantie,Yulong He,Terhi Karpanen,Marja Lohela,Helge Wiig,Petri Salven,Katri Pajusola,Ulf Eriksson,Kari Alitalo +11 more
TL;DR: Results show that full-length PDGF-D is activated in tissues and is capable of increasing interstitial fluid pressure and macrophage recruitment and the maturation of blood vessels in angiogenic processes.
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Lymphatic vessels regulate immune microenvironments in human and murine melanoma
Amanda W. Lund,Marek Wagner,Manuel Fankhauser,Eli Sihn Samdal Steinskog,Maria A. S. Broggi,Stefani Spranger,Thomas F. Gajewski,Kari Alitalo,Hans Petter Eikesdal,Helge Wiig,Melody A. Swartz,Melody A. Swartz +11 more
TL;DR: It is suggested that the establishment of tumor-associated inflammation and immunity critically depends on lymphatic vessel remodeling and drainage, and the results have implications for immunotherapies, the efficacies of which are regulated by the tumor immune microenvironment.