H
Hubert Kettenberger
Researcher at Hoffmann-La Roche
Publications - 85
Citations - 3573
Hubert Kettenberger is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Antibody & RNA polymerase II. The author has an hindex of 19, co-authored 80 publications receiving 3143 citations. Previous affiliations of Hubert Kettenberger include Ludwig Maximilian University of Munich & Max Planck Society.
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Journal ArticleDOI
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
Wolfgang Schaefer,Jörg T. Regula,Monika Bähner,Jürgen Michael Schanzer,Rebecca Croasdale,Harald Dürr,Christian Gassner,Guy Georges,Hubert Kettenberger,Sabine Imhof-Jung,Manfred Schwaiger,Kay Stubenrauch,Claudio Sustmann,Markus Thomas,Werner Scheuer,Christian Klein +15 more
TL;DR: Applying the three possible “CrossMab” formats, bispecific antibodies against angiopoietin-2 and vascular endothelial growth factor A are generated and show that they can be produced by standard techniques, exhibit stabilities comparable to natural antibodies, and bind both targets simultaneously with unaltered affinity.
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Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
TL;DR: The crystal structure of the complete 12 subunit RNA polymerase (pol) II bound to a transcription bubble and product RNA reveals incoming template and nontemplate DNA, a seven base pair DNA/RNA hybrid, and three nucleotides each of separating DNA and RNA.
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Architecture of the RNA Polymerase II-TFIIS Complex and Implications for mRNA Cleavage
TL;DR: The results support the idea that Pol II contains a single tunable active site for RNA polymerization and cleavage, in contrast to DNA polymerases with two separate active sites for DNA polymerizationand cleavage.
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Structure of eukaryotic RNA polymerases.
Patrick Cramer,Karim-Jean Armache,Sonja Baumli,Stefan Benkert,Florian Brueckner,Claudia Buchen,Gerke E. Damsma,Stefan Dengl,Sebastian R. Geiger,Anja J. Jasiak,Anass Jawhari,Stefan Jennebach,Tomislav Kamenski,Hubert Kettenberger,Claus-D. Kuhn,Elisabeth Lehmann,Kristin Leike,Jasmin F. Sydow,Alessandro Vannini +18 more
TL;DR: A catalog of available structural information for Pol I, Pol II, and Pol III is provided, which showed that the active center region and core enzymes are similar to Pol II and that strong structural differences on the surfaces account for gene class-specific functions.
Journal ArticleDOI
Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies
Christian Klein,Claudio Sustmann,Markus Thomas,Kay Stubenrauch,Rebecca Croasdale,Jürgen Michael Schanzer,Ulrich Brinkmann,Hubert Kettenberger,Jörg T. Regula,Wolfgang Schaefer +9 more
TL;DR: This review discusses the state of the art in bispecific heterodimeric IgG antibodies, with an emphasis on recent progress.