What is the function of albumin in the human body?
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Albumin is a highly abundant protein in the human body and plays multiple important roles. It acts as a carrier for various molecules in the bloodstream, including drugs, nutraceuticals, and toxic substances . Additionally, albumin helps maintain the colloidal osmotic pressure of the blood, which is crucial for regulating fluid balance . It also has enzymatic activities and can function as an esterase or pseudoesterase . Albumin possesses antioxidant properties and can trap reactive oxygen and nitrogen species, participating in redox processes . Furthermore, albumin interacts with blood cells, blood vessels, and tissue cells outside the vascular bed, contributing to vascular endothelial integrity . It has anti-inflammatory activities and is involved in maintaining the acid-base balance . Albumin is also responsible for the transport, distribution, and metabolism of various substances in the body . Overall, albumin has diverse functions and is essential for maintaining homeostasis and supporting various physiological processes in the human body.
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6 Citations | The function of albumin in the human body is to transport medicinal drugs and distribute them in the bloodstream to the site of action. |
| The paper does not explicitly mention the specific function of albumin in the human body. However, it states that albumin plays important metabolic roles, such as regulating the oncotic pressure, binding and transporting various molecules, scavenging free radicals, and modulating the immune response and blood coagulation. | |
5 Citations | The function of albumin in the human body is to act as an interface between blood plasma and the cell membrane, carrying molecules and playing a role in vascular homeostasis. |
51 Citations | Albumin plays a decisive role in the transport of various ions and molecules, maintaining the colloidal osmotic pressure of the blood. It also binds to drugs, nutraceuticals, and toxic substances, determining their pharmacokinetics and toxicokinetics. |
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Albumin interact with?5 answersAlbumin interacts with various substances such as drugs, mycotoxins, and polymeric micelles. It plays a crucial role in drug binding, affecting pharmacokinetics and pharmacodynamics. Studies have shown that different drugs bind to specific sites on albumin, influencing their affinity and potential interactions. Additionally, mycotoxins like beauvericin, cyclopiazonic acid, and sterigmatocystin form complexes with human serum albumin, impacting their toxicokinetics. Furthermore, block copolymer micelles interact with albumin, affecting their stability in the bloodstream and potential for drug delivery systems. These interactions are essential for understanding drug behavior, toxicity, and the development of novel drug delivery strategies.
Does albumin act on skeletal muscle?4 answersAlbumin has been found to have an effect on skeletal muscle. In an experimental model of sepsis, the infusion of human serum albumin (HSA) improved microvascular perfusion in skeletal muscle. Additionally, in a study using mouse C2 myotubes, periodic stretching of the muscle cells resulted in significant hypertrophy accompanied by the accumulation of albumin from the culture medium. Furthermore, albumin has been identified as a structural constituent of chicken myofibrils, with highest concentrations observed in the region where thin and thick filaments overlap. In a study on muscular dystrophies, albumin was used as a carrier to target damaged muscle fibers, demonstrating intracellular accumulation of albumin in clusters of damaged muscle fibers. Finally, a study on elderly individuals found that decreases in serum albumin concentrations were associated with muscle loss (sarcopenia).
Does albumin exist in the skin?4 answersYes, albumin exists in the skin. It has been found in the skin of frogs, specifically in the skin of Bombina maximaand Duttaphrynus melanostictus. In both cases, the albumin in the skin is distinct from the albumin found in the serum. The skin albumin in Bombina maxima is characterized by its ability to bind tightly with trypsin and inhibit its activity. It is widely distributed around the membranes of epithelial layer cells and within the dermis, suggesting its involvement in skin physiological functions such as water economy and metabolite exchange. Similarly, the skin albumin in Duttaphrynus melanostictus also exhibits trypsin inhibitory activity and is involved in skin physiological functions. These findings provide evidence that albumin is present in the skin and plays important roles in skin physiology.
What is albumin?5 answersAlbumin is a versatile protein found in human blood that has various functions and applications. It is the most abundant serum protein and can act as a carrier for therapeutic payloads, enhancing their pharmacological action. Albumin also has regenerative potential and can be used as a biomaterial in regenerative medicine, such as enhancing the biocompatibility of implants and promoting stem cell adhesion and proliferation. In addition, albumin can be utilized as a drug carrier in nanomedicines, offering advantages such as biocompatibility, tumor targeting, and sustained drug release. Furthermore, albumin plays a crucial role in modulating acid-base balance, inflammation, vascular endothelial integrity, and binding various compounds in the blood. Overall, albumin is a multifunctional protein with diverse applications in medicine and research.
How do the structure of albumin proteins relate to their functions?5 answersThe structure of albumin proteins is closely related to their functions. Albumin is the most abundant protein in blood plasma and performs various functions such as transport, antioxidant, immunomodulatory, and endothelioprotective functions. It is able to bind to drugs, nutraceuticals, and toxic substances, determining their pharmacokinetics and toxicokinetics. Different spectroscopy, thermodynamic, and in silico studies have been employed to understand how albumin binds to ligands. The albumin-binding domain found in various surface proteins of gram-positive bacteria has been used for protein purification, immobilization, and improving the pharmacokinetics of therapeutic proteins. Albumin also plays a role in tissue engineering, acting as a bacteriostatic coating and promoting cell attachment and proliferation. Furthermore, albumin has been found to have an active role in bone healing, possibly by recruiting endogenous stem cells and promoting the growth of new bone. Overall, the structure of albumin proteins is crucial for their diverse functions in the body.