What is the long term effect of supplemental androgens on the male's ability to produce sperm?
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| Papers (11) | Insight |
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45 Citations | Our study is the first to demonstrate a significant effect of short sperm longevity on the last-male sperm precedence. |
| Summary Growth and maintenance of the prostate is dependent on androgens. | |
36 Citations | Long-term 6-MP treatment in male mice did not impair sperm production and sperm morphology. |
100 Citations | This study demonstrates that the dose or route of administration of androgens is critical for sperm suppression in combined androgen-progestagen regimens for hormonal male contraception. |
| Hence, the ability of androgens to maintain spermatogenesis in vivo is partly via their effects on TJ proteins and regulation of the blood-testis barrier. | |
21 Citations | A chronic reduction in sperm quality and increased weight gain could have negative consequences on the reproductive capacity of males, and further studies should consider the effects of long-term ATZ exposure on male reproductive health. |
| Contrary to what was initially hypothesized, androgens seem to have an overall cardioprotective effect, especially in men. | |
52 Citations | It seems a defensible practice to treat aging men with androgens if and when they are testosterone-deficient, but long-term studies including sufficient numbers of men are needed. |
74 Citations | The similar survival of androgens from inbred and outbred sperm sources may be the result of high treatment mortality associated with androgenesis. |
27 Citations | This effect may be mediated by estrogens derived from testicular androgens. |
67 Citations | In conclusion, the overall effect of administration of testosterone on cardiovascular-disease risk is difficult to assess because androgens have such an extraordinary array of effects in vivo. |
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